Effects of anti-Tuberculosis Drugs on the Level of some Nutritional Factors Among Patients with tuberculosis
DOI:
https://doi.org/10.22317/jcms.v7i6.1083Keywords:
copper, zinc, M. tuberculosis, anti-tuberculosisAbstract
Objective: The study aimed to assess changes in the level of some nutritional elements including zinc and copper for tuberculosis patients before, during, and after anti-tuberculosis therapy.
Methods: Whole blood samples are collected from 120 tuberculosis patients who are admitted to specialist clinics of the respiratory diseases in Babylon province, within a period from November 2020 to January 2021.
Results: Out of whole TB patients, (66) ones were males and the remaining (54) were females, the age of patients ranging from (13-70) years. Sixty, apparently healthy control groups who had no Tuberculosis history were chosen. Using spectrophotometer for estimating the level of Zinc and copper. In TB patients the zinc level was increased during and after anti-tuberculosis therapy, but the level of zinc was lower in patients after therapy compared with controls. The level of copper was decreased during and after the course of anti-tuberculosis, but the level of copper was higher in patients after therapy compared with controls.
Conclusion: These parameters could be used in follow-up as the achievement of TB therapy success.
References
2. Bahi, G. A.; Boyvin, L.; Méité, S.; M’Boh, G. M.; Yeo, K.; N’Guessan, K. R.; Alain,A. D. P. and Allico, A. J. (2017). Assessments of serum copper and zinc concentration, and the Cu/Zn ratio determination in patients with multidrug-resistant pulmonary tuberculosis (MDR-TB) in Côte d’Ivoire. BMC Infectious Diseases.17:257.
3. Vemula, M. H; Ganji, R.; Sivangala, R.; Jakkala, K.; Gaddam, S.; Penmetsa, S. and Banerjee, S. (2016). Mycobacterium tuberculosis Zinc Metalloprotease-1 Elicits Tuberculosis-Specific Humoral Immune Response Independent of Mycobacterial Load in Pulmonary and Extra-Pulmonary Tuberculosis Patients. Front. Microbiol. 7:418.
4. Sepehri, Z.; Mirzaei, N.; Sargazi, A.; Sargazi, A.; Mishkar, A.; Kiani, Z.; Oskoee, H.; Arefib, D. and Ghavami, S. (2017). Essential and toxic metals in serum of individuals with active pulmonary tuberculosis in an endemic region. J. Clinic Tuberculosis and Other Mycobacterial Dis 6: 8–13.
5. Edem, V. F.; Ige, O. and Arinola, O. G. (2015). Plasma vitamins and essential trace elements in newly diagnosed pulmonary tuberculosis patients and at different durations of anti-tuberculosis chemotherapy. Egypt J Chest Dis Tuberc. 64: 675–679.
6. Mythili, C. and Lalitha, R. (2016). Role of Micronutrient Zinc in Pulmonary Tuberculosis. Sch. J. App. Med. Sci.,4(5A):1519-1524.
7. Reza, B.; Khalilzadeh, S.; Milanifar, A.; Hakimi, S. and Khodayari, A. (2007). Evaluation of copper, zinc, and copper/zinc ratio in serum of pulmonary tuberculosis children. Pediatric pulmonary ward, national research in the statute of tuberculosis and lung disease, Shaheed Beheshti University of Medical Sciences, Iran.
8. Al-Sa’adi, M. A. K.; Muhsin, M. A and Al-Jubouri, A.M. (2011). Studying The Effect of Zinc and copper on Cellular Immunity in Tuberculosis Patients. MJBL: 8(3).
9. Milena, L.; de Paula Ramalho, D.; Delogo, K.; Miranda, P.; Mesquita, E.; de Oliveira, H.; Netto, A.; Anjos, M.; Kritski, A. and de Oliveira, M. (2014). Association of Serum Levels of Iron, Copper, and Zinc, and Inflammatory Markers with Bacteriological Sputum Conversion During Tuberculosis Treatment. Biological Trace Element Research. 160(2): 176–184.