Histological effect of Artichoke leaf extract on bone healing in rats


  • Nawar Bahjet Kamil Department of Oral Diagnosis, College of Dentistry, University of Baghdad, Iraq.
  • Sura Saad Majeed Department of Dentistry, Al-Rafidain University College, Baghdad, Iraq.
  • Mohammed A. Salman Urosurgeon, Al Kindy teaching hospital, Ministry of Health, Baghdad, Iraq.




Artichoke oil, bone healing


Objectives: This study evaluated the effect of artichoke leaves extract on bone healing.

Methods: A total of 30 rabbits were used in the current study, 60 bone defects were made, divided into 30  bone defects left without treatment and an other 30 bone defects were treated with 0.5ml of Artichocke oil. Each group was divided randomly into three period intervals (1week, 2 and 5 weeks).

Results: Current study had showed a high significant difference between the control and the experimental group in osteoclast cells account, a significant difference in osteoblast and osteocyte cells account. Also there was a high significant difference in the formation  of the blood vessels and the trabecular bone between the experimental and the control group.

Conclusion: Artichoke leaves extract was effective and faster in bone healing without any complication in comparison with the control group.


- Safadi F., F., Barbe M.,F., Abdelmagid S., M., Rico M.,C., Aswad R.,A.,Litvin J., and Popoff S., N. 2009.Bone Structure, Development and Bone Biology . J.S. Khurana (ed.),chapter 1:1-50.

- Vanputte CL, Regan JL, Russo AF. 2013.Skeletal system: Bones and joints.In: Seeley’s Essentials of Anatomy & Physiology. 8th ed. USA: Mc Graw Hill; pp. 110-149

- OpenStax College. 2013.Anatomy & Physiology. Texas: Rice University; pp. 203-231.

- Boden SD, Schimandle JH, Hutton WC.1995. An experimental intertransverse process spinal fusion model. Radiographic, histologic, and biomechanical healing characteristics. Spine20:412–420.

-Mountziaris PM, Mikos AG. 2008.Modulation of the inflammatory response for enhanced bone tissue regeneration. Tissue Engineering Part B: Reviews; 14, 179-86.

-Thompson DD. 2003.Introduction-Mechanisms of fracture healing and pharmacologic control. J Musculoskel Neuron Interact; 3, 295-6.

- Haverstock BD, Mandracchia VJ. 1998.Cigarette smoking and bone healing: implications in foot and ankle surgery. J Foot Ankle Surg; 37, 69-74.

-Goldhahn J, Fron JM, Kanis J. 2012.Implications for fracture healing of current and new osteoporosis treatments: an ESCEO consensus paper. Calcified tissue international; 90, 343-53.

- Schindeler A, McDonald MM, Bokko P. 2008.Bone remodeling during fracture repair: the cellular picture. Semin Cell Dev Biol; 19, 459-66.

- Lattanzio V, Paul AK, Vito L, Angela C. 2009.Globe artichoke: a functional food and source of nutraceutical ingredients. J Funct Foods; 1: 131-44.

-Sonnante G, Pignone D, Hammer K. 2007.The domestication of artichoke and cardoon: from Roman times to the genomic age. Ann Bot; 100: 1095-1100.

- Ceccarelli N, Curadi M, Picciarelli P, Martelloni L, Sbrana C, Giovannetti M. 2010.Globe artichoke as functional food. Mediterranean J Nutr Metab; 3: 197-201.

- AL-Ghaban N.M.H. & Jassem G.H. 2020 . Histomorphometric evaluation of the effects of local application of red cloveroil (trifolium pratense) on bone.J Bagh.College Dentistry,32(2):26-31

- Kamboj VP .2000. Herbal Medicine. Current Science, 78, 35-9.

- Kraft K.1997. Artichoke leaf extract - Recent findings reflecting effects on lipid metabolism, liver and gastrointestinal tracts. Phytomedicine ; 4 (4): 369-378.

- Wauquier, F.; Boutin-Wittrant, L.; Viret, A.; Guilhaudis, L.; Oulyadi, H.; Bourafai-Aziez, A.; Charpentier, G.; Rousselot, G.; Cassin, E.; Descamps, S.2021.Metabolic and Anti-Inflammatory Protective Properties of Human Enriched Serum following Artichoke Leaf Extract Absorption. Nutrient; 13, 2653.

- Lupattelli G, Marchesi S, Lombardini R, Roscini AR, Trinca F, Gemelli F.2004. Artichoke juice improves endothelial function in hyperlipemia. Life Sciences; 76(7):775-82.

-Schapoval E. E. S., Winter De Vargas M. R., Chaves C. G., Bridi R., Zuanazzi J. A., Henriques A. T. 1998.Antiinflammatory and antinociceptive activities of extracts and isolated compounds from Stachytarpheta cayennensis. Journal of Ethnopharmacology;60(1):53–59.

- Wioletta Biel, Robert Witkowicz , Ewa Piątkowska & Cezary Podsiadło.2019. Proximate Composition, Minerals and Antioxidant Activity of Artichoke Leaf Extracts. Biological Trace Element Research ;194:589–595

- Vincenzo Lattanzioa, Paul A. Kroonb , Vito Linsalatac , Angela Cardinali. 2009. Globe artichoke: A functional food and source of nutraceutical ingredients. Journal of Functional Foods; 131 – 144.

- Xianfeng Zhu, Hongxun Zhang, and Raymond Lo .2004.Phenolic compounds from the leaf extract of artichoke (Cynara scolymus L.) and their antimicrobial activities.journal of Agricultural and Food Chemistry1; 52(24):7272-8

- Bonomi A, Bonomi BM, 2001. L'impiegodella farina di foglie di carciofodisidratate (Cinara scolymus L.) nell'alimentazionedeivitelloni. Rivista Di Scienzadell- Alimentazione. 30,361–370



How to Cite

Kamil, N. B. ., Majeed, S. S. ., & Salman, M. A. . (2022). Histological effect of Artichoke leaf extract on bone healing in rats. Journal of Contemporary Medical Sciences, 8(2). https://doi.org/10.22317/jcms.v8i2.1200