Relationship of Midkine in Myocardial Infarction patients and some biochemical parameters
Keywords:Myocardial infarction, Midkine, hs-CRP, AST, ALT, ALP
Objectives: This study aims to estimate the concentrations of MK, hs-CRP, TnI, AST, ALT and ALP in serum for MI in comparison to wholesome controls, in an effort to check the quantity of this impact at the pathological condition, in addition to understanding the position of MK in MI sufferers and its relationship to liver function tests and may be used as biochemical markers to decide the severity of MI in sufferers.
Methods: The studying include the investigation of midkine (MK), High-sensitivity C-reactive protein (hs-CRP), Troponin I (TnI), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and alkaline phosphatase (ALP) levels in myocardial infarction (MI) patients. The study includes (84) samples: 34 of myocardial infarction patients (19 male and 15 female) and 50 sample of apparently healthy as control group (25 male and 25 female). Samples were collected during the period from Jan. 2021 to July 2021 from in-patients of Cardiac Surgery Center admitted at Ibn Sina Teaching Hospital and Mosul General Hospital, Mosul, Iraq with matching age ranged between 26-86 years. The clinical diagnosis in each case is made according to a cardiovascular specialist.
Results: The results showed that there was a significant increase in MK, TnI, GOT, GPT and ALP for all studied groups (males and females) of MI patients compared with control groups, and there was no any a significant in hs-CRP. Beside of, showed significant positive correlation between MK with BMI, hs-CRP, TnI, AST, ALT and ALP in control and patients group. Whereas there were no any correlation between MK with age, in patients and control under study.
Conclusion: The study indicated that the MK increased in patients with myocardial infarction, and it’s increased in males more than female patients, and that may act as a good markers for diagnosis of myocardial infarction disease.
Jernberg T., Hasvold, P., Henriksson, M., Hjelm, H., Thuresson, M. and Janzon, M. (2015). Cardiovascular risk in post-myocardial infarction patients: nationwide real world data demonstrate the importance of a long-term perspective. Eur Heart J. 36 : 1163–70.
Libby, P., Buring, J.E., Badimon, L., Hansson, G.K., Deanfield, J., Bittencourt, M.S., et al. (2019). Atherosclerosis. Nat Rev Dis Primers 5 : 56.
Kosuge, M., Kimura, K., Ishikawa, T., Ebina, T., Hibi, K., Tsukahara, K., et al. (2006). Differences between men and women in terms of clinical features of ST-segment elevation acute myocardial infarction. Circulation Journal, 70(3) : 222–226.
Hemeed, R. N. ; Al-Tu’ma, F. J.; Al-Koofee, A. F. and Al-Mayali, A. H. (2020). Relationship of angiotensin converting enzyme (I/D) polymorphism (rs4646994) and coronary heart disease among a male Iraqi population with type 2 diabetes mellitus. Journal of Diabetes and Metabolic Disorders, 19(2) : 1227-1232
Valensi, P., Lorgis, L., and Cottin, Y. (2011). Prevalence, incidence, predictive factors and progno-sis of silent myocardial infarction: a review of the literature. Archives of Cardiovascular Diseases, 104(3) : 178–188.
Devlin, R. J., and Henry, J. A. (2008). Clinical review: Major consequences of illicit drug consumption. Critical Care, 12(1) : 202.
Graham, I., Atar, D., Borch-Johnsen, K., Boysen, G., Burell, G., Cifkova, R., et al. (2007). European guidelines on cardiovascular disease prevention in clinical practice: Executive summary: Fourth joint task force of the european society of cardiology and other societies on cardiovascular disease prevention in clinical practice (Constituted by representatives of nine societies and by invited experts). European Heart Journal, 28(19) : 2375–2414.
Pagliaro, B. R., Cannata, F., Stefanini, G. G., and Bolognese, L. (2020). Myocardial ischemia and coronary disease in heart failure. Heart failure reviews, 25(1) : 53–65.
Kadomatsu, K., Tomomura, M. and Muramatsu, T.(1988). cDNA Cloning and sequencing of a new gene intensely expressed in early differentiation stages of embryonal carcinoma cells and in mid-gestation period of mouse embryogenesis. Biochem Biophys Res Commun. 151: 1312–8.
Zhang, L., Song, X., Shao, Y., Wu, C. and Jiang, J. (2018). Prognostic value of midkine expression in patients with solid tumors: a systematic review and meta-analysis. Oncotarget 9 : 24821–24829.
Takada, S., Sakakima, H., Matsuyama, T., Otsuka, S., Nakanishi, K., Norimatsu, K., Itashiki, Y., Tani, A. and Kikuchi, K. (2020). Disruption of Midkine gene reduces traumatic brain injury through the modulation of neuroinflammation. Journal of Neuroinflammation, 17(1) : 40.
Weckbach, L. T., Preissner, K. T. and Deindl, E. (2018). The role of midkine in arteriogenesis, involving mechanosensing, endothelial cell proliferation, and vasodilation. Int. J. Mol. Sci., 19(9) : 2559.
Woulfe, K. C., and Sucharov, C. C. (2017). Midkine's Role in Cardiac Pathology. Journal of cardiovascular development and disease, 4(3) : 13.
Badila, E., Daraban, A.M., Tintea, E., Barto¸s, D., Alexandru, N. and Georgescu, A.(2015) Midkine proteins in cardio-vascular disease. Where do we come from and where are we heading to? Eur. J. Pharmacol. 762, 464–471.
Lackner, I., Weber, B., Baur, M., Haffner-Luntzer, M., Eiseler, T., Fois, G., et. al. (2019). Midkine Is Elevated After Multiple Trauma and Acts Directly on Human Cardiomyocytes by Altering Their Functionality and Metabolism. Frontiers in immunology, 10 : 1920.
Quispe, R., Michos, E.D., Martin, S.S., Puri, R., Toth, P.P., Al Suwaidi, J., Banach, M. and Virani, S.S., Blumenthal, R.S., Jones, S.R., et al. (2020). High-sensitivity C-reactive protein discordance with atherogenic lipid measures and incidence of atherosclerotic cardiovascular disease in primary prevention: the aric study. J. Am. Hear. Assoc. 9, e013600.
Koenig, W. (2013). High-sensitivity C-reactive protein and atherosclerotic disease: From improved risk prediction to risk-guided therapy. Int. J. Cardiol. 168 : 5126–5134.
Al-Tu’ma, F.J. ; Abd-Yasera, Z.A. and Al-Naffi, K.O. (2016). Association between hs-CRP levels and the severity of coronary atherosclerosis. J Contemp Med Sci, 2(6) : 42-44.
Adukauskiene, D., ˙ Ciginskien ˇ e, A., Adukauskait ˙ e, A., Pentiokinien ˙ e, D., Šlapikas, R. and Ceponiene, I.(2016). Clinical relevance of high ˙ sensitivity C-reactive protein in cardiology. Medicina 52, 1–10.
Silva, D. and de Lacerda, A.P.(2012). High-sensitivity C-reactive protein as a biomarker of risk in coronary artery disease. Rev. Port. Cardiol., 31 : 733–745.
Ridker, P.M., Glynn, R.J. and Hennekens, C.H. (1998). C-Reactive protein adds to the predictive value of total and hdl cholesterol in determining risk of first myocardial infarction. Circulation, 97 : 2007–2011.
Ridker, P.M., Hennekens, C.H., Buring, J.E. and Rifai, N.(2000). C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. New Engl. J. Med. 342 : 836–843.
Yoshinaga, R., Doi, Y., Ayukawa, K. and Ishikawa, S.(2017). High-sensitivity C reactive protein as a predictor of in hospital mortality in patients with cardiovascular disease at an emergency department: A retrospective cohort study. BMJ Open , 7, e015112.
Song, Y., Yang, S.K., Kim, J. & Lee, D.C. (2019). Association between C-Reactive Protein and Metabolic Syndrome in Korean Adults. Korean J. Fam. Med. 40 : 116–123.
Ammirati, E., Veronese, G., Bottiroli, M., Wang, D. W., Cipriani, M., Garascia, A., et. al. (2021).Update on acute myocarditis. Trends in cardiovascular medicine, 31(6) : 370–379.
NICE. Acute coronary syndromes in adults (QS68). 2014.
Mair, J., Lindahl, B., Hammarsten, O., Mu¨ller, C., Giannitsis, E., Huber, K., et al.(2018). How is cardiac troponin released from injured myocardium? Eur Heart J Acute Cardiovasc Care. 7(6) : 553–60.
Ebell, M.H., Flewelling, D. and Flynn, C.A.(2000). A systematic review of troponin T and I for diagnosing acute myocardial infarction. J Fam Pract. 49(6) : 550–6.
Apple, F.S., Wu, A.H.B, Sandoval, Y., Sexter, A., Love. S.A., Myers, G., et al.(2020). Sex-Specific 99th percentile upper reference limits for high sensitivity cardiac troponin assays derived using a universal sample bank. Clin. Chem. 66(3):434–44.
Djakpo, D. K., Wang, Z. Q., and Shrestha, M. (2020). The significance of transaminase ratio (AST/ALT) in acute myocardial infarction. Archives of medical sciences. Atherosclerotic diseases, 5 : e279–e283.
Shamshirian, A., Alizadeh-Navaei, R., Abedi, S., Jafarpour, H., Fazli, H., Hosseini, S., Hessami, A., et. al. (2020). Levels of blood biomarkers among patients with myocardial infarction in comparison to control group. Ethiopian Journal of Health Sciences, 30(1), 5–12.
Mc Gill, M.R. (2016). The past and present of serum aminotransferases and the future of liver injury biomarkers. EXCLI J 15 : 817-28.
Gjin, N., (2021). Aspartate aminotransferase and cardiovascular disease a narrative review. Journal of Laboratory and Precision Medicine 6(6) : 1-17.
Panh, L., Ruidavets, J. B., Rousseau, H., Petermann, A., Bongard, V., Bérard, E., et. al. (2017). Association between serum alkaline phosphatase and coronary artery calcification in a sample of primary cardiovascular prevention patients. Atherosclerosis, 260 : 81–86.
Vimalraj S. (2020). Alkaline phosphatase: Structure, expression and its function in bone mineralization. Gene, 754 : 144855.
Birrer, R., Takuda ,Y. and Takara, T. (2007). Hypoxic hepatopathy: patho-physiology and prognosis. Intern Med. 46(14) : 1063–70.
Golabi, P., Stepanova, M., Pham, H.T., Cable, R., Rafiq, N., Bush, H., et al.(2018). Non-alcoholic steatofibrosis (NASF) can independently predict mortality in patients with non-alcoholic fatty liver disease (NAFLD). BMJ Open Gastroenterol. 5(1) : e000198.
Kim, D., Kim, W.R., Kim, H.J. and Therneau, T.M.(2013). Association between noninvasive fibrosis markers and mortality among adults with nonalcoholic fatty liver disease in the United States. Hepatology. 57(4) : 1357– 65.
Simon, T.G., Corey, K.E., Cannon, C.P., Blazing, M., Park, J.G., O’Donoghue, M.L., et al. (2018). The nonalcoholic fatty liver disease (NAFLD) fibrosis score, cardiovascular risk stratification and a strategy for secondary prevention with ezetimibe. International Journal of Cardiology. 270 : 245–52.
Soumya, R. S., Raj, K. B., and Abraham, A. (2021). Passiflora edulis (var. Flavicarpa) Juice Supplementation Mitigates Isoproterenol induced Myocardial Infarction in Rats. Plant Foods for Human Nutrition, 76(2) : 189–195.
Ross-Munro, E., Kwa, F., Kreiner, J., Khore, M., Miller, S. L., Tolcos, M., Fleiss, B. and Walker, D. W. (2020). Midkine: The who, what, where, and when of a promising neurotrophic therapy for perinatal brain injury. Frontiers in Neurology, 11 : 568814.
Fan, N., Sun, H., Wang, Y., Zhang, L., Xia, Z., Peng, L., et. al. (2014). Midkine, a potential link between obesity and insulin resistance. PloS one, 9(2) : e88299.
Cernkovich, E.R., Deng, J., Hua, K. and Harp, J.B. (2007). Midkine is an autocrine activator of signal transducer and activator of transcription 3 in 3T3-L1 cells. Endocrinology 148 : 1598–1604.
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