The effectiveness of topical Arnebia euchroma Oil in the treatment of Pressure Ulcer: A Case Report
Arnebia euchroma Oil in the treatment of Pressure Ulcer
Keywords:Pressure ulcer, Wound healing, Arnebia euchroma, Bed sore, Traditional Persian medicine
Decreased tissue blood flow causes pressure ulcers due to prolonged pressure on the area, which becomes problematic for immobile individuals. The medical community has often been involved in curing such a problem in individuals with disabilities and immobility. To alleviate this problem, therefore, plenty of investigations are always seeking novel methods. Furthermore, herbal plants are increasingly used owing to the accepted status of plant-derived drugs in recent years. Our female case aged 52 years that was referred to the wound clinic complaining sensory and motor weakness of the upper extremity and sudden paralysis of the lower extremity as of 1 year ago, which was diagnosed as myelitis. She complained of two wounds on both sides of the right and left buttocks with a size of 9 × 5 and another 6 × 4.5 cm from 3 months ago, and a wound with a size of 5 × 4.5 in the sacral area (sacrum) from 20 days prior to the admission. There was tissue necrosis without muscle engagement, osteomyelitis, or tunneling; besides, nasty odors and sludge were absent accounted for in class 3 in the group of wounds. She received starting therapy using Arnebia euchroma oil. As of the 2nd week onward, she was treated very successfully, and the complete wound healing occurred in 8 weeks. The use of A. euchroma for wound healing and reducing infection and inflammation can greatly contribute to the cure of pressure ulcers and can be properly suggested in healing these ulcers.
Akhkand SS, Seidi J, Ebadi A, Gheshlagh RG. Prevalence of pressure ulcer in Iran's intensive care units: A systematic review and a meta-analysis. Nursing Practice Today 2020; 7: 21-9.
Potter PA, Perry AG, Stockert P, Hall A. Fundamentals of Nursing-E-Book: Elsevier health sciences; 2016.
Rush BD, Brown-Kramer JM, Sabalka LA, Gansemer BS, Upton CT, Bauer PB, et al. Medical environment bedsore detection and prevention system. Google Patents; 2020.
Mervis JS, Phillips TJ. Pressure ulcers: Pathophysiology, epidemiology, risk factors, and presentation. Journal of the American Academy of Dermatology 2019; 81: 881-90.
Mitchell A. Adult pressure area care: preventing pressure ulcers. British Journal of Nursing 2018; 27: 1050-2.
Reilly EF, Karakousis GC, Schrag SP, Stawicki SP. Pressure ulcers in the intensive care unit: the “forgotten” enemy. Opus 2007; 12: 17-30.
Çelik S, Dirimeşe E, Taşdemir N, Aşik S, Demircan S, Eyican S, et al. Pressure sore prevention and treatment knowledge of nurses [Hemşirelerin basi yarasini önleme ve yönetme bilgisi]. 2017.
Moore ZE, Patton D. Risk assessment tools for the prevention of pressure ulcers. Cochrane Database of Systematic Reviews 2019.
Moore Z, Cowman S. Pressure ulcer prevalence and prevention practices in care of the older person in the Republic of Ireland. Journal of Clinical Nursing 2012; 21: 362-71.
Dobson R. Half of general practices offer patients complementary medicine. BMJ 2003; 327: 1250.
Bluestein D, Javaheri A. Pressure ulcers: prevention, evaluation, and management. American family physician 2008; 78: 1186-94.
Gefen A, Brienza D, Edsberg L, Milton W, Murphy C, Oomens C, et al. The etiology of pressure injuries. Prevention and Treatment of Pressure Ulcers/Injuries: Clinical Practice Guideline European Pressure Ulcer Advisory Panel (EPUAP), National Pressure Injury Advisory Panel (NPIAP) and the Pan Pacific Pressure Injury Alliance (PPPIA) 2019: 2019.
Gefen A, Brienza DM, Cuddigan J, Haesler E, Kottner J. Our contemporary understanding of the aetiology of pressure ulcers/pressure injuries. International Wound Journal 2021.
Ghodela N, Dudhamal T. Management of Bed Sores with Thumari Gel [Securinega leucopyrus (Willd.) Muell.]-An Extra-pharmacopeal Drug-A Case Study. International Journal of AYUSH Case Reports 2018; 2: 20-5.
Wound O. WOCN 2016 Guideline for Prevention and Management of Pressure Injuries (Ulcers). Journal of Wound, Ostomy and Continence Nursing 2017; 44: 241-6.
Organization WH. WHO launches the first global strategy on traditional and alternative medicine. Geneva: World Health Organization; 2002. 2014.
Nidadavolu P, Amor W, Tran PL, Dertien J, Colmer-Hamood JA, Hamood AN. Garlic ointment inhibits biofilm formation by bacterial pathogens from burn wounds. Journal of medical microbiology 2012; 61: 662-71.
Annan K, Houghton PJ. Antibacterial, antioxidant and fibroblast growth stimulation of aqueous extracts of Ficus asperifolia Miq. and Gossypium arboreum L., wound-healing plants of Ghana. Journal of Ethnopharmacology 2008; 119: 141-4.
Shahzad MN, Ahmed N. Effectiveness of Aloe vera gel compared with 1% silver sulphadiazine cream as burn wound dressing in second degree burns. J Pak Med Assoc 2013; 63: 225-30.
Ghobadi A, Yousefi A, Behnoud N. Medicinal and nutritional properties of Ziziphus jujuba Mill. in traditional persian medicine and modern phytotherapy.
Bahrami R, Ghobadi A, Behnoud N, Akhtari E. Medicinal properties of Daucus carota in traditional Persian medicine and modern phytotherapy. J Biochem Tech 2018; 9: 107-14.
Behnoud N, Bahrami R, Kordafshari G, Farzaneh F, Kenari HM. Management of early menopause using traditional Persian medicine: a case report. International Journal of Women's Health and Reproduction Sciences 2019; 7: 231-6.
Ito H, Asmussen S, Traber DL, Cox RA, Hawkins HK, Connelly R, et al. Healing efficacy of sea buckthorn (Hippophae rhamnoides L.) seed oil in an ovine burn wound model. Burns 2014; 40: 511-9.
Aliasl J, Barikbin B, Khoshzaban F, Naseri M, Sedaghat R, Kamalinejad M, et al. Effect of Arnebia euchroma ointment on post-laser wound healing in rats. Journal of Cosmetic and Laser Therapy 2015; 17: 41-5.
Kim SH, Kang I-C, Yoon TJ, Park YM, Kang K-S, Song GY, et al. Antitumor activities of a newly synthesized shikonin derivative, 2-hyim-DMNQ-S-33. Cancer letters 2001; 172: 171-5.
Saghafi MM, Fatemi MJ, Bagheri T, Hablolvarid MH, Niazi M, Saberi M, et al. The effect of Arnebia euchroma ointment on healing of deep second-degree burn wound in rat. Tehran University Medical Journal 2018; 75: 790-6.
Chawla K, Mopuri R, Sharma AK, Kumar P. Arnebia euchroma. Himalayan Medicinal Plants: Elsevier; 2021. p. 27-41.
Aghili Khorasani M. Makhzan al-Advie. Tehran: Iran University of Medical Science Research. Institute for Islamic and Complementary Medicine 2008.
Aghili MH. Gharabadin kabir. Tehran: Research Institute for Islamic and Complementary Medicine 2008.
EZ E. Daghaegh-al-Elaj [Accurate Subjects About Therapeutics]. Translated by Kermani MK Kerman: Saadat Publication 1983; 1: 433-60.
Kumar A, Shashni S, Kumar P, Pant D, Singh A, Verma RK. Phytochemical constituents, distributions and traditional usages of Arnebia euchroma: A review. Journal of Ethnopharmacology 2021: 113896.
Nasiri E, Hosseinimehr SJ, Azadbakht M, Akbari J, Enayati-Fard R, Azizi S, et al. The healing effect of Arnebia euchroma ointment versus silver sulfadiazine on burn wounds in rat. World journal of plastic surgery 2015; 4: 134.
Moghadari M, Rezvanipour M, Mehrabani M, Ahmadinejad M, Tajadini H, Hashempur MH. Efficacy of mummy on healing of pressure ulcers: A randomized controlled clinical trial on hospitalized patients in intensive care unit. Electronic physician 2018; 10: 6140.
Nasiri E, Hosseinimehr SJ, Hosseinzadeh AZ, Azadbakht M, Akbari J, Azadbakht M. The effects of Arnebia euchroma ointment on second-degree burn wounds: a randomized clinical trial. Journal of Ethnopharmacology 2016; 189: 107-16.
ALI ES, HOSSEINZADEH M. Comparison of the Effects of Oral Arnebia Euchroma and Oral ANGIPARS on Wounds in Diabetic Rats. International Journal of Pharmaceutical Research 2019; 11.
Sedaghat R, Moghadam M, Naseri M, Davati A. HISTOLOGICAL EVALUATION OF THE ANTI-INFLAMMATORY EFFECTS OF ALKANNA TINCTORIA ON THE CUTANEOUS WOUNDS HEALING IN RAT. HORMOZGAN MEDICAL JOURNAL 2010.
Liu H, Jin Y-S, Song Y, Yang X-N, Yang X-W, Geng D-S, et al. Three new compounds from Arnebia euchroma. Journal of Asian natural products research 2010; 12: 286-92.
Papageorgiou V, Assimopoulou A, Ballis A. Alkannins and shikonins: a new class of wound healing agents. Current medicinal chemistry 2008; 15: 3248-67.
Cao H, Zhang W, Liu D, Hou M, Liu S, He W, et al. Identification, in vitro evaluation and modeling studies of the constituents from the roots of Arnebia euchroma for antitumor activity and STAT3 inhibition. Bioorganic chemistry 2020; 96: 103655.
Maklebust J, Sieggreen M. Pressure ulcers: Guidelines for prevention and management: Lippincott Williams & Wilkins; 2001.
Khorasani MA. Gharabadin e kabir (persian). 1. 2011.
Karayannopoulou M, Tsioli V, Loukopoulos P, Anagnostou TL, Giannakas N, Savvas I, et al. Evaluation of the effectiveness of an ointment based on Alkannins/Shikonins on second intention wound healing in the dog. Canadian Journal of Veterinary Research 2011; 75: 42-8.
AHMADIAN AM, MONSEF EH, AMIN GR, Fazeli M, Jamalifar H, Kamalinia G, et al. The ethnopharmacological study on antibacterial activity of some selected plants used in Iranian traditional medicine. 2009.
Damianakos H, Kretschmer N, Sykłowska-Baranek K, Pietrosiuk A, Bauer R, Chinou I. Antimicrobial and cytotoxic isohexenylnaphthazarins from Arnebia euchroma (Royle) Jonst.(Boraginaceae) callus and cell suspension culture. Molecules 2012; 17: 14310-22.
Akkol EK, Koca U, Peşin I, Yılmazer D, Toker G, Yeşilada E. Exploring the wound healing activity of Arnebia densiflora (Nordm.) Ledeb. by in vivo models. Journal of Ethnopharmacology 2009; 124: 137-41.
Pirbalouti AG, Koohpayeh A, Azizi S, Golparvar A, editors. Evaluation of the burn healing properties of Arnebia euchroma rolye (johnst) in diabetic rats. Int Conference Biosci Biochem Bioinform; 2011.
Pirbalouti AG, Azizi S, Koohpayeh A. Healing potential of Iranian traditional medicinal plants on burn wounds in alloxan-induced diabetic rats. Revista Brasileira de Farmacognosia 2012; 22: 397-403.
Ashkani-Esfahani S, Imanieh M, Khoshneviszadeh M, Meshksar A, Noorafshan A, Geramizadeh B, et al. The healing effect of arnebia euchroma in second degree burn wounds in rat as an animal model. Iranian Red Crescent Medical Journal 2012; 14: 70.
How to Cite
Copyright (c) 2023 Journal of Contemporary Medical Sciences
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.