Relation of serum and follicular level of BMP15 with Oocyte quality, embryo grading and pregnancy rate

Authors

  • Zainab Hassan Hashim Department of Clinical Reproductive Physiology, High Institution for Infertility Diagnosis and Assisted Reproductive Technologies, University of Al-Nahrain, Baghdad, Iraq.
  • Lubna Amer Institution for Infertility Diagnosis and Assisted Reproductive Technologies, University of Al-Nahrain, Baghdad, Iraq.
  • Estabraq A. Al-Wasiti Department of Biochemistry, College of Medicine, University of Al-Nahrain, Baghdad, Iraq.

DOI:

https://doi.org/10.22317/jcms.v8i5.1283

Keywords:

Follicular Level, BMP15, Oocyte, Embryo Grading, Pregnancy Rate

Abstract

Objectives: Use of serum and follicular fluid concentration of oocyte secreted factors BMP15 as biomarkers of oocyte quality, embryo quality and it's relation to pregnancy rate.

Methods: Eighty eight women were included in this study; they were selected from those undergoing intra-cytoplasmic sperm injection.

Results: Positive pregnancy was achieved by 14 women accounting for 19.0 % (total number of women that reach embryo transfer was 72). No significant difference in mean serum BMP15 between pregnant and non- pregnant women, but the level of follicular fluid BMP15 was significantly higher in pregnant women. MI oocyte count was not significantly correlated to serum or follicular fluid BMP15 (p > 0.05). MII oocyte count showed highly significant positive correlation to serum and follicular fluid BMP15 (p < 0.01). Grade1 embryo count showed highly significant positive correlation to serum and follicular fluid BMP15 (p < 0.01), Grade 2 embryo count showed significant positive correlation to serum BMP15 (p = 0.032), but the grade 2 embryo count showed non- significant correlation to follicular BMP15 (p > 0.05). Also grade 3 embryo count showed non- significant correlation to serum and follicular BMP15 (p > 0.05).

Conclusions: The current study revealed that  serum and follicular BMP15 could be used as indicator for oocyte maturity, and serum BMP15 could be used as indicator of good quality embryos.

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Published

2022-10-26

How to Cite

Hashim, Z. H. ., Amer, L. ., & Al-Wasiti, E. A. . (2022). Relation of serum and follicular level of BMP15 with Oocyte quality, embryo grading and pregnancy rate. Journal of Contemporary Medical Sciences, 8(5). https://doi.org/10.22317/jcms.v8i5.1283