Association between hormonal Imbalance and Interleulin-10 level with Polycystic Ovarian Syndrome of Iraqi women
DOI:
https://doi.org/10.22317/jcms.v8i5.1285Keywords:
Interleukin-10, Polycystic Ovary Syndrome, IraqAbstract
Objectives: To determine the level of interleukin-10 as inflammatory marker in PCOS patients and compared with healthy control and explore the correlation between IL-10 level and other biochemical markers in PCOS patients.
Methods: Whole blood samples of 80 PCOS obese patients and 80 healthy people were collected in duration from Dec., 2021 to April, 2022, at the gynecological and obstetric teaching hospital, Kerbala health directorate, Iraq. The Rotterdam criteria-2003 was accepted to PCOS females with age range between (18-40 years), while the apparently control group with age ranged between (18-40 years). BMI and WHR and hormonal status (LH, FSH, LH/FSH ratio, Prolactin, Free Testosterone) were determined. Elabscience/USA ELISA kit uses the Sandwich-ELISA principle was used to determined IL-10 level in serum.
Results: The obese PCOS women had a seriously decrease in IL-10 (pg/ml) level when compare with apparently healthy control group with mean ± SD for patients (2.192 ± 0.47) and for control group (4.532 ± 0.75) P value < 0.0001, and there are significant negative correlations between IL-10 and (BMI p<0.0001, r= -0.66), (WHR p<0.0001, r= -0.66), (LH p<0.0001, r= -0.63), (LH: FSH ratio p<0.0001, r= -0.72), (Prolactin p=0.008, r= -029).
Conclusion: Our findings indicate that the IL-10 level decrease in PCOS obese patients and has significant association with pathogenesis and progression of disease.
References
- Abraham Gnanadass, S., Divakar Prabhu, Y. & Valsala Gopalakrishnan, A. 2021. Association Of Metabolic And Inflammatory Markers With Polycystic Ovarian Syndrome (Pcos): An Update. Archives Of Gynecology And Obstetrics, 303, 631-643.
- Ahmed, I., Ali, I. & Hussain, S. 2022. Human Body Weight Measures In Association With Better Screening Predictor Among Waist-To-Hip Ratio, Body Mass Index And Body Fat Percentage. Bahria University Journal Of Humanities & Social Sciences, 5.
- Artimani, T., Karimi, J., Mehdizadeh, M., Yavangi, M., Khanlarzadeh, E., Ghorbani, M., Asadi, S. & Kheiripour, N. 2018. Evaluation Of Pro-Oxidant-Antioxidant Balance (Pab) And Its Association With Inflammatory Cytokines In Polycystic Ovary Syndrome (Pcos). Gynecological Endocrinology, 34, 148-152.
- Bakiri, A. H. & Mingomataj, E. Ç. 2019. Novel Insights On Interleukin-10 Functions: A Manipulative Tool For The Deviation Of Immune Response And Disease Outcome. Emj Allergy Immunol, 4, 88-94.
- Cabus, U., Kabukcu, C., Fenkci, S., Caner, V., Oztekin, O., Fenkci, V. & Enli, Y. 2020. Serum Caspase-1 Levels In Women With Polycystic Ovary Syndrome. Taiwanese Journal Of Obstetrics And Gynecology, 59, 207-210.
- Chugh, R. M., Park, H.-S., El Andaloussi, A., Elsharoud, A., Esfandyari, S., Ulin, M., Bakir, L., Aboalsoud, A., Ali, M. & Ashour, D. 2021. Mesenchymal Stem Cell Therapy Ameliorates Metabolic Dysfunction And Restores Fertility In A Pcos Mouse Model Through Interleukin-10. Stem Cell Research & Therapy, 12, 1-19.
- Gnanadass, S. A., Prabhu, Y. D. & Gopalakrishnan, A. V. 2021. Association Of Metabolic And Inflammatory Markers With Polycystic Ovarian Syndrome (Pcos): An Update. Archives Of Gynecology And Obstetrics, 1-13.
- Karadeniz, M., Erdogan, M., Zengi, A., Tamsel, S., Berdeli, A., Saygili, F. & Yilmaz, C. 2008. Polymorphism Of The Interleukin‐10 Gene In Polycystic Ovary Syndrome. International Journal Of Immunogenetics, 35, 119-123.
- Milewska, M., Przekop, Z., Szostak-Węgierek, D., Chrzanowska, M., Raciborski, F., Traczyk, I., Sińska, B. I. & Samoliński, B. 2022. Prevalence Of Risk Of Sarcopenia In Polish Elderly Population—A Population Study. Nutrients, 14, 3466.
- Moore, K. W., De Waal Malefyt, R., Coffman, R. L. & O'garra, A. 2001. Interleukin-10 And The Interleukin-10 Receptor. Annual Review Of Immunology, 19, 683-765.
- Nissar, S., Sameer, A. S. & Banday, M. Z. 2021. Genetic Polymorphisms Of Essential Immune Pathogenic Response Genes And Risk Of Cervical Cancer. Genetic Polymorphism And Cancer Susceptibility. Springer.
- Park, K. S., Gang, W., Kim, P.-W., Yang, C., Jun, P., Jung, S.-Y., Kwon, O., Lee, J. M., Lee, H. J. & Lee, S. J. 2022. Efficacy And Safety Of Acupuncture On Oligomenorrhea Due To Polycystic Ovary Syndrome: An International Multicenter, Pilot Randomized Controlled Trial. Medicine, 101, E28674-E28674.
- Ralston, S. H. & De Crombrugghe, B. 2006. Genetic Regulation Of Bone Mass And Susceptibility To Osteoporosis. Genes & Development, 20, 2492-2506.
- Rasquinha, M. T., Sur, M., Lasrado, N. & Reddy, J. 2021. Il-10 As A Th2 Cytokine: Differences Between Mice And Humans. The Journal Of Immunology, 207, 2205-2215.
- Rostamtabar, M., Esmaeilzadeh, S., Tourani, M., Rahmani, A., Baee, M., Shirafkan, F., Saleki, K., Mirzababayi, S. S., Ebrahimpour, S. & Nouri, H. R. 2021. Pathophysiological Roles Of Chronic Low‐Grade Inflammation Mediators In Polycystic Ovary Syndrome. Journal Of Cellular Physiology, 236, 824-838.
- Said, E. A., Dupuy, F. P., Trautmann, L., Zhang, Y., Shi, Y., El-Far, M., Hill, B. J., Noto, A., Ancuta, P. & Peretz, Y. 2010. Programmed Death-1–Induced Interleukin-10 Production By Monocytes Impairs Cd4+ T Cell Activation During Hiv Infection. Nature Medicine, 16, 452-459.
- Shamsi, M., Ghazavi, A., Saeedifar, A. M., Mosayebi, G. & Ganji, A. 2022. The Immune System’s Role In Pcos. Molecular Biology Reports, 1-14.
- Sözen, T., Özişik, L. & Başaran, N. Ç. 2017. An Overview And Management Of Osteoporosis. European Journal Of Rheumatology, 4, 46.
- Sylus, A. M., Nandeesha, H. & Chitra, T. 2020. Matrix Metalloproteinase-9 Increases And Interleukin-10 Reduces With Increase In Body Mass Index In Polycystic Ovary Syndrome: A Cross-Sectional Study. International Journal Of Reproductive Biomedicine, 18, 605.
- Talaat, R. M., Mohamed, Y. A., Mohamad, E. H., Elsharkawy, M. & Guirgis, A. A. 2016. Interleukin 10 (− 1082 G/A) And (− 819 C/T) Gene Polymorphisms In Egyptian Women With Polycystic Ovary Syndrome (Pcos). Meta Gene, 9, 254-258.
- Umar, M., Sastry, K. S. & Chouchane, A. I. 2018. Role Of Vitamin D Beyond The Skeletal Function: A Review Of The Molecular And Clinical Studies. International Journal Of Molecular Sciences, 19, 1618.
- Vural, P., Değirmencioğlu, S., Saral, N. Y. & Akgül, C. 2010. Tumor Necrosis Factor Α (− 308), Interleukin-6 (− 174) And Interleukin-10 (− 1082) Gene Polymorphisms In Polycystic Ovary Syndrome. European Journal Of Obstetrics & Gynecology And Reproductive Biology, 150, 61-65.
- Wang, W., Zheng, J., Cui, N., Jiang, L., Zhou, H., Zhang, D. & Hao, G. 2019. Baicalin Ameliorates Polycystic Ovary Syndrome Through Amp-Activated Protein Kinase. Journal Of Ovarian Research, 12, 1-12.
- Yang, Y., Xia, J., Yang, Z., Wu, G. & Yang, J. 2021. The Abnormal Level Of Hsp70 Is Related To Treg/Th17 Imbalance In Pcos Patients. Journal Of Ovarian Research, 14, 1-9.
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