Role of Apo E and superoxide dismutase in patients with obstructive lung diseases

Authors

  • Anwar J Almzaiel Department of biochemistry, College of Medicine, University of Alqadisiyah
  • Ali Mansoor Jasim Al-Ameri Department of Microbiology and Immunology, Department of Microbiology and Immunology, College of Medicine, University of Kerbala
  • Rafad Tariq Department of Biochemistry, College of Medicine, University of Kerbala

DOI:

https://doi.org/10.22317/jcms.v3i9.136

Abstract

Objective Obstructive lung diseases (OLD) are chronic inflammatory disorders of the respiratory tract including asthma and chronic obstructive pulmonary disease (COPD). Apo lipoprotein E (Apo E) is a multifunctional protein as it intervenes the binding of lipoproteins or lipid complexes to specific cell-surface receptors. Experimental studies referred to the function of Apo E as an endogenous negative regulator of airway hyper responsiveness and goblet cell hyperplasia. The protective role of Apo E pathways primarily in respiratory disease was explained in human studies and research utilizing experimental murine model systems. Literature data reveal a strong association between redox status, including the enzyme superoxide dismutase (SOD) with both the development a severity of OLD. This study aims to investigate the relation between SOD antioxidant enzyme activity in addition to investigating the level of Apo E and the development of obstructive lung diseases (OLD).

Methods Patients with OLD (n = 40) and 40 age-matched healthy controls were enrolled in this study. Serum samples were collected to test the role of Apo E and to test the effect of antioxidant enzyme SOD, and their influence on OLD, all measured by ELISA.

Result The results showed a significant decrease in the level of serum SOD activity in patients with OLD when compared with control group (P < 0.05). However, the levels of Apo E did not show a significant difference between the two groups.

Conclusion Decreased level of antioxidant SOD suggests the presence of an oxidative stress in asthmatic airways favoring a more oxidative state is present in the airway inflammation. The level of Apo E was non significantly increased in serum of patient, this suggests that protein level of Apo E does not change but may be Apo E gene expression is altered.

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Published

2017-03-26

How to Cite

Almzaiel, A. J., Al-Ameri, A. M. J., & Tariq, R. (2017). Role of Apo E and superoxide dismutase in patients with obstructive lung diseases. Journal of Contemporary Medical Sciences, 3(9), 189–192. https://doi.org/10.22317/jcms.v3i9.136

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Articles