Novel Cavity Disinfectants and Their Effects: A Review

Authors

  • Şemsi Alp Department of Restorative Dentistry, Near East University, Nicosia, Cyprus.

DOI:

https://doi.org/10.22317/jcms.v10i3.1488

Keywords:

Cavity Disinfectants, Lasers, Ozone, Hyaluronic Acid, Propolis

Abstract

Objective: This review aims to assess the efficacy of various materials and systems, including Chlorhexidine Digluconate, Benzalkonium Chloride, Hydrogen Peroxide, Sodium Hypochlorite, Iodine, Aloe Vera, Hyaluronic Acid, Propolis, Ozone, Photoactivated Disinfection, Lasers, and Antibacterial Dentin Adhesives, in cavity disinfection.

Methods: A comprehensive review of literature and studies was conducted to evaluate the effectiveness of the mentioned materials and systems for cavity disinfection.

Results: The review revealed diverse effects of Chlorhexidine Digluconate, Benzalkonium Chloride, Hydrogen Peroxide, Sodium Hypochlorite, Iodine, Aloe Vera, Hyaluronic Acid, Propolis, Ozone, Photoactivated Disinfection, Lasers, and Antibacterial Dentin Adhesives on cavity disinfection. The findings highlight the potential of these agents and technologies in enhancing disinfection protocols in dental practice.

Conclusion: This review underscores the importance of exploring various materials and systems for cavity disinfection to improve dental treatment outcomes. Further research and clinical trials are warranted to validate the efficacy and safety of these agents and technologies in dental settings.

References

Pitts NB, Zero DT, Marsh PD, et al. Dental caries. Nat Rev Dis Prim; 3. Epub ahead of print 2017. DOI: 10.1038/nrdp.2017.30.

Desai H, Stewart CA, Finer Y. Minimally invasive therapies for the management of dental caries—a literature review. Dent J 2021; 9: 1–27.

Dinç AGDG. Kavite dezenfektanlarının antibakteriyel özellikleri, bağlanma dayanımı ve mikrosızıntı üzerine etkileri (derleme). Atatürk Üniversitesi Diş Hekim Fakültesi Derg; 2012, https://dergipark.org.tr/tr/pub/ataunidfd/issue/2470/31571 (2012, accessed 31 January 2023).

Dalkilic EE, Arisu HD, Kivanc BH, et al. Effect of different disinfectant methods on the initial microtensile bond strength of a self-etch adhesive to dentin. LASERS Med Sci 2012; 27: 819–825.

Askar H, Krois J, Göstemeyer G, et al. Secondary caries: what is it, and how it can be controlled, detected, and managed? Clin Oral Investig 2020; 24: 1869–1876.

Karpiński T, Szkaradkiewicz A. Chlorhexidine--pharmaco-biological activity and application. Eur Rev Med Pharmacol Sci.

Bin-Shuwaish MS. Effects and Effectiveness of Cavity Disinfectants in Operative Dentistry: A Literature Review. J Contemp Dent Pract 2016; 17: 867–879.

Garg J, RG SM, Sinha S, et al. Antimicrobial Activity of Chlorhexidine and Herbal Mouthwash Against the Adherence of Microorganism to Sutures After Periodontal Surgery: A Clinical Microbiological Study. Cureus; 14. Epub ahead of print 24 December 2022. DOI: 10.7759/CUREUS.32907.

Cheung HY, Wong MMK, Cheung SH, et al. Differential actions of chlorhexidine on the cell wall of bacillus subtilis and escherichia coli. PLoS One; 7. Epub ahead of print 2012. DOI: 10.1371/journal.pone.0036659.

Mcdonell G, Russell A.Denvar. Antiseptics and Disinfectants: Activity, Action, and Resistance. Clin Microbiol Rev 1999; 12: 147–179.

Mao QQ, Xu XY, Cao SY, et al. Bioactive Compounds and Bioactivities of Ginger (Zingiber officinale Roscoe). Foods; 8. Epub ahead of print 1 June 2019. DOI: 10.3390/FOODS8060185.

Arslan S, Yazici AR, Görücü J, et al. Comparison of the effects of Er,Cr:YSGG laser and different cavity disinfection agents onmicroleakage of current adhesives. Lasers Med Sci 2012; 27: 805–811.

Pereira BMP, Tagkopoulos I. Benzalkonium Chlorides: Uses, Regulatory Status, and Microbial Resistance. Appl Environ Microbiol; 85. Epub ahead of print 7 July 2019. DOI: 10.1128/AEM.00377-19.

Maillard JY. Impact of benzalkonium chloride, benzethonium chloride and chloroxylenol on bacterial antimicrobial resistance. J Appl Microbiol 2022; 133: 3322–3346.

Hacıoğulları İ, Ulusoy N, Cengiz E. Derin Dentin Çürükleri̇ni̇Tedavi̇si̇nde Alternati̇f Yeni̇ Yöntemler. Atatürk Üniversitesi Diş Hekim Fakültesi Derg 2016; 26: 120–16.

Urban MV, Rath T, Radtke C. Hydrogen peroxide (H2O2): a review of its use in surgery. Wien Med Wochenschr 2019; 169: 222–225.

Abuhaimed TS, Neel EAA. Sodium Hypochlorite Irrigation and Its Effect on Bond Strength to Dentin. Biomed Res Int; 2017. Epub ahead of print 2017. DOI: 10.1155/2017/1930360.

Fani M, Kohanteb J. Inhibitory activity of Aloe vera gel on some clinically isolated cariogenic and periodontopathic bacteria. J Oral Sci 2012; 54: 15–21.

Abatangelo G, Vindigni V, Avruscio G, et al. Hyaluronic Acid: Redefining Its Role. Cells 2020; 9: 1–19.

Marinho A, Nunes C, Reis S. Hyaluronic Acid: A Key Ingredient in the Therapy of Inflammation. Biomolecules; 11. Epub ahead of print 1 October 2021. DOI: 10.3390/BIOM11101518.

Sukumar S, Drízhal I. Hyaluronic acid and periodontitis. Acta Medica (Hradec Kralove) 2007; 50: 225–228.

Ghisalberti EL. Propolis: A Review. http://dx.doi.org/101080/0005772X197911097738 2015; 60: 59–84.

Sardana D, Indushekar K, Manchanda S, et al. Role of propolis in dentistry: Review of the literature. Focus Altern Complement Ther 2013; 18: 118–125.

El Meligy OA, Elemam NM, Talaat IM. Ozone Therapy in Medicine and Dentistry: A Review of the Literature. Dent J; 11. Epub ahead of print 1 August 2023. DOI: 10.3390/DJ11080187.

Xue W, Macleod J, Blaxland J. The Use of Ozone Technology to Control Microorganism Growth, Enhance Food Safety and Extend Shelf Life: A Promising Food Decontamination Technology. Foods; 12. Epub ahead of print 1 February 2023. DOI: 10.3390/FOODS12040814.

Batakliev T, Georgiev V, Anachkov M, et al. Ozone decomposition. Interdiscip Toxicol 2014; 7: 47.

Domb WC. Ozone Therapy in Dentistry A Brief Review for Physicians. Interv Neuroradiol 2014; 20: 632–636.

Barczyk I, Masłyk D, Walczuk N, et al. Potential Clinical Applications of Ozone Therapy in Dental Specialties—A Literature Review, Supported by Own Observations. Int J Environ Res Public Health; 20. Epub ahead of print 2023. DOI: 10.3390/ijerph20032048.

Sharma V, Nainan M, Shivanna V. The effect of cavity disinfectants on the sealing ability of dentin bonding system: An in vitro study. J Conserv Dent 2009; 12: 109.

Alhamdan EM. Influence of contemporary photoactivated disinfection on the mechanical properties and antimicrobial activity of PMMA denture base: A systematic review and meta analysis. Photodiagnosis Photodyn Ther 2023; 42: 1572–1000.

Nazemisalman B, Farsadeghi M, Sokhansanj M. Types of Lasers and Their Applications in Pediatric Dentistry. J Lasers Med Sci 2015; 6: 96.

Pelagalli J, Gimbel CB, Hansen RT, et al. Investigational study of the use of Er:YAG laser versus dental drill for caries removal and cavity preparation--phase I. J Clin Laser Med Surg 1997; 15: 109–115.

Lusche I, Dirk C, Frentzen M, et al. Cavity Disinfection With a 445 nm Diode Laser Within the Scope of Restorative Therapy – A Pilot Study. J Lasers Med Sci 2020; 11: 417.

Mehl A, Kremers L, Salzmann K, et al. 3D volume-ablation rate and thermal side effects with the Er:YAG and Nd:YAG laser. Dent Mater 1997; 13: 246–251.

Freitas PM, Navarro RS, Barros JA, et al. The use of Er:YAG laser for cavity preparation: An SEM evaluation. Microsc Res Tech 2007; 70: 803–808.

Siso HS, Kustarci A, Goktolga EG. Microleakage in resin composite restorations after antimicrobial pre-treatments: effect of KTP laser, chlorhexidine gluconate and Clearfil Protect Bond. Oper Dent 2009; 34: 321–327.

Lopes SR, Matuda AGN, Campos RP, et al. Development of an Antibacterial Dentin Adhesive. Polymers (Basel); 14. Epub ahead of print 1 June 2022. DOI: 10.3390/POLYM14122502.

Gou Y ping, Meghil MM, Pucci CR, et al. Optimizing resin-dentin bond stability using a bioactive adhesive with concomitant antibacterial properties and anti-proteolytic activities. Acta Biomater 2018; 75: 171–182.

ELİGÜZELOĞLU E. Son dönem geliştirilen adeziv sistemler. Ondokuz Mayıs Üniv Diş Hekim Derg 2009; 10: 22–29.

Imazato S. Bio-active restorative materials with antibacterial effects: new dimension of innovation in restorative dentistry. Dent Mater J 2009; 28: 11–19.

Rezaeian Z, Beigi-Boroujeni S, Atai M, et al. A novel thymol-doped enamel bonding system: Physico-mechanical properties, bonding strength, and biological activity. J Mech Behav Biomed Mater; 100. Epub ahead of print 1 December 2019. DOI: 10.1016/J.JMBBM.2019.103378.

Zhao M, Qu Y, Liu J, et al. A universal adhesive incorporating antimicrobial peptide nisin: effects on Streptococcus mutans and saliva-derived multispecies biofilms. Odontology 2020; 108: 376–385.

Shin JM, Gwak JW, Kamarajan P, et al. Biomedical applications of nisin. J Appl Microbiol 2016; 120: 1449–1465.

Huahua T, Rudy J, Kunin CM. Effect of Hydrogen Peroxide on Growth of Candida, Cryptococcus, and Other Yeasts in Simulated Blood Culture Bottles. J Clin Microbiol 1991; 29: 328–332.

Baysan A, Whiley RA, Lynch E. Antimicrobial effect of a novel ozone- generating device on micro-organisms associated with primary root carious lesions in vitro. Caries Res 2000; 34: 498–501.

Imazato S, Kuramoto A, Takahashi Y, et al. In vitro antibacterial effects of the dentin primer of Clearfil Protect Bond. Dent Mater 2006; 22: 527–532.

Mutluay AT, Mutluay M. Effects of Different Disinfection Methods on Microleakage of Giomer Restorations. Eur J Dent 2019; 13: 569.

Oznurhan F, Ozturk C, Ekci ES. Effects of different cavity-disinfectants and potassium titanyl phosphate laser on microtensile bond strength to primary dentin. Niger J Clin Pract 2015; 18: 400–404.

Patri G, Sahu A. Role of Herbal Agents - Tea Tree Oil and Aloe vera as Cavity Disinfectant Adjuncts in Minimally Invasive Dentistry-An In vivo Comparative Study. J Clin Diagn Res 2017; 11: DC05–DC09.

Prabhakar AR, Karuna YM, Yavagal C, et al. Cavity disinfection in minimally invasive dentistry - comparative evaluation of Aloe vera and propolis: A randomized clinical trial. Contemp Clin Dent 2015; 6: S24–S31.

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Published

2024-07-02

How to Cite

Alp, Şemsi. (2024). Novel Cavity Disinfectants and Their Effects: A Review. Journal of Contemporary Medical Sciences, 10(3). https://doi.org/10.22317/jcms.v10i3.1488