Preptin as a Potential Marker in Iraqi Newly Diagnosed T2DM and T2DM with Cardiovascular Disease
DOI:
https://doi.org/10.22317/jcms.v10i2.1490Keywords:
Diabetes mellitus (T2DM), CVD, Preptin, Lipid ProfileAbstract
Objective: The aim of present work is to study the Role of preptin level in Iraqi type 2 diabetes patients and related with other biochemical parameters.
Methods: This study was including (88) partespents, (22) newly diagnosed T2DM, (22) T2DM and (22) ischemic heart disease with T2DM, and (22) as healthy control, age ranged (35-63) years.
Results: The findings indicate that individuals with type 2 diabetes mellitus (T2DM) exhibited markedly elevated levels of FBS, HbA1C, insulin, HOMA-IR, TC, TG, LDL-C, VLDL-C, and preptin in comparison to the control group. These differences were statistically significant (p<0.0001). Moreover, the Pearson correlation analysis revealed that preptin levels were positively associated with FBS, HbA1c, TC, TG, LDL, VLDL, insulin, and HOMA-IR while exhibiting a negative correlation with HDL.
Conclusion: Because preptin plays a critical function in controlling sugar metabolism and, consequently, sugar problems, excessive levels of preptin play a significant role in the patient's inability to control both their level of glycosylated hemoglobin and their blood sugar levels. preptin levels are therefore high in diabetics and those with heart disease, which results in a loss of control over the body's metabolism and exposes a patient to many other ailments.
References
Jedda WAAL, Al-Ali ZAJR, Akram RS. Study the Interferon–γ, C-reactive Protein and Lipid Profile in Iraqi Diabetic Patients With and Without Hypertension. NVEO-NATURAL VOLATILES Essent OILS Journal| NVEO. 2021;8820–32.
Ali WM. Factors associated with poor glycemic control in diabetic patients in Kirkuk. Kirkuk Journal of Medical Sciences. 2022 May 1;10(1):87-97.
Kitabchi AE, Umpierrez GE, Miles JM, Fisher JN. Hyperglycemic crises in adult patients with diabetes. Diabetes Care. 2009;32(7):1335–43.
Elias NG, Akram RS, Abd Aon YS. Alteration of lipid profile, kidney functions, D-dimer and some anti-inflammatory parameters in samples of Iraqi patients with Covid-19. J Popul Ther Clin Pharmacol. 2023;30(5):515–25.
Akram RS, Isaa MQ, Mohammed AA. Fetuin-A levels and Insulin Resistance in Obese and Non-Obese Iraqi Children. J Popul Ther Clin Pharmacol. 2023;30(6):414–20.
Faris Rija F, Sulaiman Musa MI, Hamad HT. Some Biochemical Parameters and Level of Preptin in Newly Diagnosed Type 2 Diabetic Women Patients in Tikrit City. J Chem Heal Risks. 2022;12(2):179–82.
Smarr T, Clements JN. The Underutilization of Pramlintide as Adjunct Therapy in Type 1 and Type 2 Diabetes. ADCES Pract. 2023;2633559X221150809.
Mathiesen DS, Lund A, Holst JJ, Knop FK, Lutz TA, Bagger JI. THERAPY OF ENDOCRINE DISEASE: Amylin and calcitonin–physiology and pharmacology. Eur J Endocrinol. 2022;186(6):R93–111.
Nyirjesy SC, Peleckis AJ, Eiel JN, Gallagher K, Doliba A, Tami A, Flatt AJ, De Leon DD, Hadjiliadis D, Sheikh S, Stefanovski D, Gallop R, D'Alessio DA, Rubenstein RC, Kelly A, Rickels MR. Effects of GLP-1 and GIP on Islet Function in Glucose-Intolerant, Pancreatic-Insufficient Cystic Fibrosis. Diabetes. 2022 Oct 1;71(10):2153-2165. doi: 10.2337/db22-0399. PMID: 35796669; PMCID: PMC9501647.
Khalili, D., Khayamzadeh, M., Kohansal, K. et al. Are HOMA-IR and HOMA-B good predictors for diabetes and pre-diabetes subtypes?. BMC Endocr Disord 23, 39 (2023). https://doi.org/10.1186/s12902-023-01291-9.
Association AD. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2014;37(Supplement_1):S81–90.
Tahir NT, Falih IQ, Alkubaisi MR, Alabdaly AR. Apelin as a Potential Marker in Iraqi Children with Type 1 Diabetes Mellitus. J Contemp Med Sci| Vol. 2023 ,9(6):408-12.
Ungureanu, M.-C.; Bilha, S.C.; Hogas, M.; Velicescu, C.; Leustean, L.; Teodoriu, L.C.; Preda, C. Preptin: A New Bone Metabolic Parameter? Metabolites 2023, 13, 991. https://doi.org/10.3390/metabo13090991
Abbas A, Ali HA, AL-Rufaie MM, Ali RA. Association of serum preptin levels with insulin resistance in Iraqi women with gestational diabetes mellitus. Int Res J Pharm. 2019;10:49–55.
Li B, Li Y, Zhang T, Song L, Lei C, Zhao Y, et al. Preptin is a new predictor of coronary artery calcification. Clin Chim Acta. 2018;485:133–8.
Aydin S. Discovery of ghrelin hormone: research and clinical applications. Turk J Biochem. 2007;32:76–89.
Hamzah MI, Kareem IAA, Albayati M. Expression of Amylin and Preptinin Iraqi Patients with Type 2 Diabetes Mellitus. Exec Ed. 2020;11(01):1272.
Kıraç UI, Demır E, Ozkan H, Sahtıyancı B, Uzun H, Ekıncı I, Buyukkaba M, Durmus S, Akarsu M, Gelisgen R, Tabak O. Maternal serum preptin levels in the pathogenesis and diagnosis of Gestational diabetes mellitus. J Med Biochem. 2023 Mar 15;42(2):311-317. doi: 10.5937/jomb0-36287. PMID: 36987416; PMCID: PMC10040191.
Salman Hasan MS, Mashkur MS, Ranaei Siadat SO, Ali HA. Assessment of Serum Afamin and Preptin Levels as a Potential Diagnosis Markers for Cardiovascular Patients Undergoing Catheterization. Medico-Legal Updat. 2020;20(2).
Wang H, Wang X, Cao Y, Han W, Guo Y, Yang G, et al. Association of polymorphisms of preptin, irisin and adropin genes with susceptibility to coronary artery disease and hypertension. Medicine (Baltimore). 2020;99(10).
Gupta A, Singh SK, Padmavathi BN, Rajan SY, Mamatha GP, Kumar S, et al. Evaluation of correlation of blood glucose and salivary glucose level in known diabetic patients. J Clin diagnostic Res JCDR. 2015;9(5):ZC106.
El-Eshmawy M, Abdel Aal I. Relationships between preptin and osteocalcin in obese, overweight, and normal weight adults. Appl Physiol Nutr Metab. 2015;40(3):218–22.
Hirata A, Okamura T, Hirata T, Sugiyama D, Ohkubo T, Okuda N, Kita Y, Hayakawa T, Kadota A, Kondo K, Miura K, Okayama A, Ueshima H. Relationship Between Non-fasting Triglycerides and Cardiovascular Disease Mortality in a 20-year Follow-up Study of a Japanese General Population: NIPPON DATA90. J Epidemiol. 2022 Jul 5;32(7):303-313. doi: 10.2188/jea.JE20200399. Epub 2021 Jun 22. PMID: 33456020; PMCID: PMC9189318.
Tada H, Nomura A, Yoshimura K, Itoh H, Komuro I, Yamagishi M, Takamura M, Kawashiri MA. Fasting and non-fasting triglycerides and risk of cardiovascular events in diabetic patients under statin therapy. Circulation Journal. 2020 Feb 25;84(3):509-15. 24. Ballantyne CM, Olsson AG, Cook TJ, Mercuri MF, Pedersen TR, Kjekshus J. Influence of low high-density lipoprotein cholesterol and elevated triglyceride on coronary heart disease events and response to simvastatin therapy in 4S. Circulation. 2001;104(25):3046–51.
Sacks, F. M., & Campos, H. (2003). Low-density lipoprotein size and cardiovascular disease: a reappraisal. The Journal of Clinical Endocrinology & Metabolism, 88(10), 4525-4532.
Jung E, Kong SY, Ro YS, Ryu HH, Shin SD. Serum Cholesterol Levels and Risk of Cardiovascular Death: A Systematic Review and a Dose-Response Meta-Analysis of Prospective Cohort Studies. Int J Environ Res Public Health. 2022 Jul 6;19(14):8272. doi: 10.3390/ijerph19148272. PMID: 35886124; PMCID: PMC9316578.
Baigent C, Blackwell L, Emberson J, Holland LE, Reith C, Bhala N, et al. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials. Lancet (London, England). 2010;376(9753):1670–81.
Thair Tahir N, Akram RS, Al-Rubae’i SHN, SH Nsaif A. Vitamin D3 status and insulin resistance in Iraqi patients with osteoarthritis disease in Baghdad governorate-Iraq. In: AIP Conference Proceedings. AIP Publishing LLC; 2022. p. 30015.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Journal of Contemporary Medical Sciences
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
