MicroRNA-5196 as an Accurate Biomarker of Disease Activity and Response to Treatment in Rheumatoid Arthritis
DOI:
https://doi.org/10.22317/jcms.v10i2.1520Keywords:
miRNA-5196, Rheumatoid Arthritis, TNF inhibitor, RAAbstract
Objective:
Methods: One hundred patients divided into two groups’ 50 responders and 50 non responders with 50 healthy individuals were studied. The serum expression ofmiRNA-5196 was detected by using real-time polymerase chain reaction.
Results: miRNA-5196 expression was significantly higher in rheumatoid arthritis patients versus control group P <0.05. Sub-group of patients into responders and non-responders showed that miRNA-5196 expression higher in non-responders than responders.miRNA-5196 expression related with response to TNF-α inhibitor and disease activity in patients with rheumatoid arthritis.
Conclusion: miRNA-5196 may consider as a valid target for monitoring progression of RA disease and response to TNF-α inhibitor therapy.
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