Evaluation of Inflammatory Markers in Patients with Fibromyalgia Syndrome in King Abdulaziz University Hospital (KAUH) in Jeddah, Saudi Arabia: A Cross-Sectional Study
DOI:
https://doi.org/10.22317/jcms.v10i3.1580Keywords:
Keywords: Fibromyalgia syndrome, neutrophil/lymphocyte ratio, platelet distribution width, mean platelet volumeAbstract
Objectives: The goal of this study was to examine various markers in patients with FMS, including the neutrophil/lymphocyte ratio (NLR),
platelet/lymphocyte ratio (PLR), platelet distribution width (PDW), and mean platelet volume (MPV).
Methods: This was a cross-sectional, retrospective study conducted at King Abdulaziz University Hospital (KAUH) in Jeddah, Saudi Arabia,
involving the examination of inflammatory markers, such as PDW, NLR, and MPV. The results were evaluated with IBM SPSS version 25, and a P-value of <0.05 was used to reject the null hypothesis.
Results: In total, 396 participants were included in this study: 235 in the FMS group and 161 in the control group. MPV, PDW and NLR values are 10.31 ± 1.6 fL, 124.57 ± 70.0, 2.30 ± 3.2, respectively. The PDW in the control group (12.47 ± 2.5) was significantly higher than that in the FMS group (11.84 ± 2.4) (P = 0.003). Erythrocyte sedimentation rate and Vitamin D levels (P = 0.001) were significantly higher in the control group than in the FMS group, with values of 31.71 and 24.2 and 75.60 and 39.4, respectively. No significant differences were found in MPV and NLR values between the FMS and control groups.
Conclusion: The findings in this study suggest that PDW and PLR are important inflammatory markers that may be beneficial in FMS
diagnosis.
References
Clauw DJ (2014) Fibromyalgia: a clinical review. JAMA 311(15):1547-1555. https://doi.org/10.1001/jama.2014.3266
Goldenberg DL (1987) Fibromyalgia syndrome. An emerging but controversial condition. JAMA 257(20):2782-2787. https://doi.org/10.1001/jama.257.20.2782
Pomares FB, Funck T, Feier NA, Roy S, Daigle-Martel A, Ceko M, Narayanan S, Araujo D, Thiel A, Stikov N, Fitzcharles MA, Schweinhardt P (2017) Histological Underpinnings of Grey Matter Changes in Fibromyalgia Investigated Using Multimodal Brain Imaging. The Journal of neuroscience: the official journal of the Society for Neuroscience 37(5):1090-1101. https://doi.org/10.1523/jneurosci.2619-16.2016
Sarzi-Puttini P, Atzeni F, Mease PJ (2011) Chronic widespread pain: from peripheral to central evolution. Best practice & research Clinical rheumatology 25(2):133-139. https://doi.org/10.1016/j.berh.2011.04.001
Fuller-Thomson E, Nimigon-Young J, Brennenstuhl S (2012) Individuals with fibromyalgia and depression: findings from a nationally representative Canadian survey. Rheumatology international 32(4):853-862. https://doi.org/10.1007/s00296-010-1713-x
Busch AJ, Webber SC, Richards RS, Bidonde J, Schachter CL, Schafer LA, Danyliw A, Sawant A, Dal Bello-Haas V, Rader T, Overend TJ (2013) Resistance exercise training for fibromyalgia. The Cochrane database of systematic reviews 2013(12):Cd010884. https://doi.org/10.1002/14651858.Cd010884
Queiroz LP (2013) Worldwide epidemiology of fibromyalgia. Current pain and headache reports 17(8):356. https://doi.org/10.1007/s11916-013-0356-5
Galizia G, Lieto E, Zamboli A, De Vita F, Castellano P, Romano C, Auricchio A, Cardella F, De Stefano L, Orditura M (2015) Neutrophil to lymphocyte ratio is a strong predictor of tumor recurrence in early colon cancers: A propensity score-matched analysis. Surgery 158(1):112-120. https://doi.org/10.1016/j.surg.2015.02.006
Taşoğlu I, Çiçek OF, Lafci G, Kadiroğullari E, Sert DE, Demir A, Cavus U, Colak N, Songur M, Hodo B (2014) Usefulness of neutrophil/lymphocyte ratio as a predictor of amputation after embolectomy for acute limb ischemia. Annals of vascular surgery 28(3):606-613. https://doi.org/10.1016/j.avsg.2012.12.009
Uslu AU, Deveci K, Korkmaz S, Aydin B, Senel S, Sancakdar E, Sencan M (2013) Is neutrophil/lymphocyte ratio associated with subclinical inflammation and amyloidosis in patients with familial Mediterranean fever? BioMed research international 2013:185317. https://doi.org/10.1155/2013/185317
Köşüş N, Köşüş A, Turhan NO (2011) Relationship of ovarian volume with mean platelet volume and lipid profile in patients with polycystic ovary syndrome. Experimental and therapeutic medicine 2(6):1141-1144. https://doi.org/10.3892/etm.2011.327
Delgado-García G, Galarza-Delgado D, Colunga-Pedraza I, Borjas-Almaguer OD, Mandujano-Cruz I, Benavides-Salgado D, Martínez-Granados RJ, Atilano-Díaz A (2016) Mean platelet volume is decreased in adults with active lupus disease. Revista brasileira de reumatologia 56(6):504-508. https://doi.org/10.1016/j.rbre.2016.03.003
Peng YF, Huang YX, Wei YS (2016) Altered mean platelet volume in patients with polymyositis and its association with disease severity. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 49(6):e5168. https://doi.org/10.1590/1414-431x20165168
Vagdatli E, Gounari E, Lazaridou E, Katsibourlia E, Tsikopoulou F, Labrianou I (2010) Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia 14(1):28-32
Aktürk S, Büyükavcı R (2017) Evaluation of blood neutrophil-lymphocyte ratio and platelet distribution width as inflammatory markers in patients with fibromyalgia. Clinical rheumatology 36(8):1885-1889. https://doi.org/10.1007/s10067-017-3647-0
Rodriguez-Pintó I, Agmon-Levin N, Howard A, Shoenfeld Y (2014) Fibromyalgia and cytokines. Immunology letters 161(2):200-203. https://doi.org/10.1016/j.imlet.2014.01.009
Bote ME, García JJ, Hinchado MD, Ortega E (2014) An exploratory study of the effect of regular aquatic exercise on the function of neutrophils from women with fibromyalgia: role of IL-8 and noradrenaline. Brain, behavior, and immunity 39:107-112. https://doi.org/10.1016/j.bbi.2013.11.009
İlgün E, Akyürek Ö, Kalkan AO, Demir F, Demirayak M, Bilgi M (2016) Neutrophil/Lymphocyte Ratio and Platelet/Lymphocyte Ratio in Fibromyalgia. Electronic Journal of General Medicine 13(2):100-104. https://doi.org/ 10.15197/ejgm.1525
Ege F, Isik R (2023) A Comparative Assessment of the Inflammatory Markers in Patients with Fibromyalgia under Duloxetine Treatment. Frontiers in bioscience (Landmark edition) 28(8):161. https://doi.org/10.31083/j.fbl2808161
Çintesun E, Akar S, Gul A, Çintesun FNI, Sahin G, Ezveci H, Akyürek F, Çelik Ç (2019) Subclinical inflammation markers in hyperemesis gravidarum and ketonuria: A case-control study. Journal of laboratory physicians 11(2):149-153. https://doi.org/10.4103/jlp.Jlp_151_18
Guntel M, Uysal A (2021) Detecting the presence of inflammation in fibromyalgia syndrome with neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and mean platelet volume. Ann Med Res 28(4):0722-0725
Kılıç E, Rezvani A, erek toprak A, Erman H, Ayhan S, Poyraz E, Ozaras N (2016) Evaluation of Neutrophil to Lymphocyte and Platelet to Lymphocyte Ratios in Rheumatoid Arthritis. Dicle Med J 43(2):241-247. https://doi.org/10.5798/diclemedj.0921.2016.02.0674
Molina F, Del Moral ML, La Rubia M, Blanco S, Carmona R, Rus A (2019) Are Patients With Fibromyalgia in a Prothrombotic State? Biological research for nursing 21(2):224-230. https://doi.org/10.1177/1099800418824716
Al-Nimer MSM, Mohammad TAM, Alsakeni RA (2018) Serum levels of serotonin as a biomarker of newly diagnosed fibromyalgia in women: Its relation to the platelet indices. Journal of research in medical sciences: the official journal of Isfahan University of Medical Sciences 23:71. https://doi.org/10.4103/jrms.JRMS_859_17
Karlıbel İ. A., Demirci H, Kasapoğlu M, Türe DA, Altan L (2021) The relationship between vitamin 25(OH)D level and hematological parameters in newly diagnosed women with fibromyalgia syndrome. J Surg Med 5(1):61-65. https://doi.org/10.28982/josam.746743
von Känel R, Müller-Hartmannsgruber V, Kokinogenis G, Egloff N (2014) Vitamin D and central hypersensitivity in patients with chronic pain. Pain medicine (Malden, Mass) 15(9):1609-1618. https://doi.org/10.1111/pme.12454
Amin OA, Abouzeid SM, Ali SA, Amin BA, Alswat KA (2019) Clinical association of vitamin D and serotonin levels among patients with fibromyalgia syndrome. Neuropsychiatric disease and treatment 15:1421-1426. https://doi.org/10.2147/ndt.S198434
D'Souza RS, Lin G, Oh T, Vincent A, Orhurhu V, Jiang L, Mauck WD, Qu W (2020) Fibromyalgia Symptom Severity and Psychosocial Outcomes in Fibromyalgia Patients with Hypovitaminosis D: A Prospective Questionnaire Study. Pain medicine (Malden, Mass) 21(12):3470-3478. https://doi.org/10.1093/pm/pnz377
Korkmaz MD, Medin CC, . 2022;14(3):251-254 (2022) Evaluation of Inflammatory Markers in Fibromyalgia Syndrome. İKSSTD 14(3):251-254. https://doi.org/10.14744/iksstd.2022.85547
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