Analysis of Extrauterine Leiomyoma and Leiomyosarcoma; A Retrospective 5 years study
DOI:
https://doi.org/10.22317/jcms.v11i6.2072Keywords:
Leiomyoma, Leiomyosarcoma, Extrauterine Diseases, Ovarian Neoplasms, Soft Tissue NeoplasmsAbstract
Objectives: The aim of the study was to investigate non-uterine Leiomyoma and Leiomyosarcoma among cases undergoing histopathological assessment due to vague nature at Duhok Province.
Methods: A retrospective cross-sectional study was conducted on patients diagnosed with leiomyoma/leiomyosarcoma in a single histopathological center in collaboration with several general surgery outpatient clinics. All patients were resident at Duhok governorate, Kurdistan Region, Iraq. The duration of the collected sample was 5 years, and the study took 3 months for data collection and entry between October 2024 and March 2025.
Results: Upon histopathological assessment, 95.91% were Leiomyoma while Leiomyosarcoma represented only 4.09%. The commonest location was the ovaries (89.9%) for the general sample and 26.67% among Leiomyosarcoma. The prevalence was one third in males (33.33%) and 3.85% in females, with P = 0.0102 and a relative risk of leiomyosarcoma in males 8.67 times that of females, with an odds ratio of 12.5. Younger age groups were more likely to suffer from leiomyosarcoma (P < 0.001).
Conclusion: Leiomyoma and Leiomyosarcoma can be found outside the uterine cavity, and diagnosis requires histopathological assessment. Further studies on the disease are required to highlight the importance of the extra-uterine form of the disease in the human body.
References
Barjon K, Kahn J, Singh M. Uterine leiomyomata. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025.
Mathew R, Francis S, Jayaram V, Anvarsadath S. Uterine leiomyomas revisited with review of literature. Abdom Radiol (NY). 2021;46:4908–26. doi:10.1007/s00261-021-03126-4.
Sandberg A. Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: leiomyoma. Cancer Genet Cytogenet. 2005;158(1):1–26. doi:10.1016/j.cancergencyto.2004.08.025.
Saurabh S. A case report of uterine fibroid with broad ligament fibroid. Int J Curr Res Rev. 2023. doi:10.31782/ijcrr.2023.151602.
Veeresh M, Sudhakara M, Girish G, Naik C. Leiomyoma: a rare tumor in the head and neck and oral cavity: report of 3 cases with review. J Oral Maxillofac Pathol. 2013;17(2):281–7. doi:10.4103/0973-029X.119770.
Chouchane A, Boughizane S, Nouira M, et al. Benign metastasizing leiomyoma: new insights into a rare disease with an obscure etiopathogenesis. Diagn Pathol. 2024;19:2. doi:10.1186/s13000-023-01427-4.
Robinson E, Neugut AI, Wylie P. Clinical aspects of postirradiation sarcomas. J Natl Cancer Inst. 1988;80(4):233–40. doi:10.1093/jnci/80.4.233.
George S, Serrano C, Hensley ML, Ray-Coquard I. Soft tissue and uterine leiomyosarcoma. J Clin Oncol. 2018;36(2):144–50. doi:10.1200/JCO.2017.75.9845.
Florence AM, Fatehi M. Leiomyoma. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan. Available from: https://www.ncbi.nlm.nih.gov/books/NBK538273/
Ricci S, Stone R, Fader A. Uterine leiomyosarcoma: epidemiology, contemporary treatment strategies and the impact of uterine morcellation. Gynecol Oncol. 2017;145(1):208–16. doi:10.1016/j.ygyno.2017.02.019.
Leibsohn S, D’Ablaing G, Mishell D, Schlaerth J. Leiomyosarcoma in a series of hysterectomies performed for presumed uterine leiomyomas. Am J Obstet Gynecol. 1990;162(4):968–74; discussion 974–6. doi:10.1016/0002-9378(90)91298-Q.
Mikami Y. Histopathology of uterine leiomyoma. In: Histopathology of Uterine Tumors. 2018:1–21. doi:10.1007/978-981-10-7167-6_1.
Lundeberg K, Vidis L, Martin J, Randolph-Habecker J. Invaluable role of histopathology in the diagnosis of cutaneous leiomyosarcoma in insulin injection site reaction. BMJ Case Rep. 2021;14:e241333. doi:10.1136/bcr-2020-241333.
Mathew B, Gupta D, Gahlot G. Cutaneous leiomyosarcoma of penile prepuce: a rare case. IP Arch Cytol Histopathol Res. 2024. doi:10.18231/j.achr.2024.043.
Kumari S, Yadav G, Kaushik B, Kumar A, Phulware R, Singh A, et al. Histopathological spectrum of leiomyoma of the uterus with an emphasis on pathological technique to avoid the misdiagnosis: a single tertiary centre experience. J Med Evid. 2023;4:225–30. doi:10.4103/jme.jme_151_22.
Hilliard N, Heslin M, Castro C. Leiomyosarcoma of the inferior vena cava: three case reports and review of the literature. Ann Diagn Pathol. 2005;9(5):259–66. doi:10.1016/j.anndiagpath.2005.05.001.
Rao U, Finkelstein S, Jones M. Comparative immunohistochemical and molecular analysis of uterine and extrauterine leiomyosarcomas. Mod Pathol. 1999;12(11):1001–9.
Kerrison W, Thway K, Jones R, Huang P. The biology and treatment of leiomyosarcomas. Crit Rev Oncol Hematol. 2023;103955. doi:10.1016/j.critrevonc.2023.103955.
Bao Y, Yang X, Zhao Q, Li W. Analysis of demographics and treatment outcomes for gastrointestinal leiomyosarcoma based on the SEER database. Sci Rep. 2025;15. doi:10.1038/s41598-025-91758-7.
Valzacchi G, Rosas P, Uzal M, Gil S, Viglierchio V. Incidence of leiomyosarcoma at surgery for presumed uterine fibroids in different age groups. J Minim Invasive Gynecol. 2020. doi:10.1016/j.jmig.2019.06.013.
Rodriguez A, Zeybek B, Aşoglu M, Sak M, Tan A, Borahay M, Kilic G. Incidence of occult leiomyosarcoma in presumed morcellation cases: a database study. Eur J Obstet Gynecol Reprod Biol. 2016;197:31–5. doi:10.1016/j.ejogrb.2015.11.009.
Leibsohn S, D’Ablaing G, Mishell D, Schlaerth J. Leiomyosarcoma in a series of hysterectomies performed for presumed uterine leiomyomas. Am J Obstet Gynecol. 1990;162(4):968–74; discussion 974–6. doi:10.1016/0002-9378(90)91298-Q.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Journal of Contemporary Medical Sciences

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

