Is salivary evaluation of P53 and MMP-3 a good tool for early detection of oral squamous cell carcinoma?


  • Shima Nafarzadeh
  • mohsen emamgholipour Dentistry student, Student Research Committee, Babol University of Medical Sciences , Babol, Iran
  • Fatimah Bijani
  • Hamed Hosseinkazemi
  • Amrollah Mostafazadeh
  • Oveis Khakbaz
  • Fatemeh Baladi
  • Sorayya Khafri


OSCC, P53, MMP3, Saliva, ELISA


Objective: Oral squamous cell carcinoma is one of the most common malignancies around the world. Despite the advancement in treatment methods, the prognosis is still not good. Based on clinicians’ idea, the early diagnosis of the lesion can lead to better prognosis. Some salivary biomarkers such as matrix metalloproteinase-3 and P53 may detect OSCC in early stages. In this study we wanted to compare salivary MMP-3 and P53 levels in OSCC patients and control group.

Methods: Fifteen patients with OSCC (9 males and 6 females) were selected from oral pathology department, Babol, Iran.  Salivary MMp-3 and P53 were measured by ELISA and compared with control group. Data was analyzed by ANOVA, T test, and Mann-Whitney.

Results: There was no significant differences between salivary MMP-3 and P53 concentration in patients with OSCC and healthy individuals.

Conclusion: Based on our findings and other similar studies, salivary MMP-3 and P53 levels might not be accurate enough to detect early stages of oral SCC. But there are controversial statements about these questions. So supplementary studies are needed to be done in future.


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How to Cite

Nafarzadeh, S., emamgholipour, mohsen, Bijani, F., Hosseinkazemi, H., Mostafazadeh, A., Khakbaz, O., Baladi, F., & Khafri, S. (2018). Is salivary evaluation of P53 and MMP-3 a good tool for early detection of oral squamous cell carcinoma?. Journal of Contemporary Medical Sciences, 4(3). Retrieved from



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