The efficacy of traditional formulation on quality of life and fatigue in multiple sclerosis patients: a randomized double-blind placebo-control clinical trial
DOI:
https://doi.org/10.22317/jcms.v5i2.569Abstract
Objective: According to effects that cinnamon, ajwain and Iranian borago shows in involving mechanisms in MS and MS animal model, we decided to survey the affect of traditional formulation on MS patient by clinical trial.
Methods: in a double blind randomized clinical trial study, 60 patients with (MS) observed. They take formulation 15cc per day, fill the MSQOL-54, and fatigue questionnaires every month. The data were analyzed with 18th version of SPSS, independent t-Test and repeated measure tests. The p-value for tests was 0.05.
Results: the mean quality of life and fatigue of patient with MS were significantly changed during 3 month.
Conclusion: most patients with MS had better quality of life during 3 month and get less tired. In some patient tremor and pain reduce. Because of good result and revenue of formulation, it seems to be useful for MS patient.
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29. Petramfar P, Moein M, Samani SM, Tabatabaei SH, Zarshenas MMJNS. Trachyspermum ammi 10% topical cream versus placebo on neuropathic pain, a randomized, double-blind, placebo-controlled trial. 2016;37(9):1449-55.
2. Goldenberg MMJP, Therapeutics. Multiple sclerosis review. 2012;37(3):175.
3. Siddiqui MK, Khurana IS, Budhia S, Hettle R, Harty G, Wong SLJCmr, et al. Systematic literature review and network meta-analysis of cladribine tablets versus alternative disease-modifying treatments for relapsing–remitting multiple sclerosis. 2018;34(8):1361-71.
4. Honda K, Jacobson JSJPm. Use of complementary and alternative medicine among United States adults: the influences of personality, coping strategies, and social support. 2005;40(1):46-53.
5. Olsen SAJOTI. A review of complementary and alternative medicine (CAM) by people with multiple sclerosis. 2009;16(1):57-70.
6. Schwarz S, Knorr C, Geiger H, Flachenecker PJMSJ. Complementary and alternative medicine for multiple sclerosis. 2008;14(8):1113-9.
7. Hamedi A, Zarshenas MM, Sohrabpour M, Zargaran AJPb. Herbal medicinal oils in traditional Persian medicine. 2013;51(9):1208-18.
8. Nimrouzi M, Zare MJJoe-bc, medicine a. Principles of nutrition in Islamic and traditional Persian medicine. 2014;19(4):267-70.
9. Arzani M. Tib Akbari. Qom: Jalal-eddin; 2008.
10. Jorjani S. Medical objectives and excellent researches (Al-aghraz al-tibbieh va al-mabahes al-alayieh). 1st ed. Tehran: Tehran University Press; 2006.
11. Kermani NiE. sharh-ol-asbab va Alamat. (in persian). 1st ed. Qom: Jalaledin; Research Institute for Islamic and Complementary Medicine (RICM); 2008.
12. Nazem Khan Cheshti NJM. Eksire Azam. Dehli: Nami Monshi Nolkshur.1315:38-70.
13. Sina AA. Canon of Medicine. Tehran: Soroosh Press; 1988.
14. Singh G, Maurya S, Catalan C, De Lampasona MJJoA, chemistry f. Chemical constituents, antifungal and antioxidative effects of ajwain essential oil and its acetone extract. 2004;52(11):3292-6.
15. Zarshenas MM, Moein M, Samani SM, Petramfar PJJonr. An overview on ajwain (Trachyspermum ammi) pharmacological effects; modern and traditional. 2013;14(1):98-105.
16. Miraj S, Kiani SJDPL. A review study of therapeutic effects of Iranian borage (Echium amoenum Fisch). 2016;8(6):102-9.
17. Dugoua J-J, Seely D, Perri D, Cooley K, Forelli T, Mills E, et al. From type 2 diabetes to antioxidant activity: a systematic review of the safety and efficacy of common and cassia cinnamon bark. 2007;85(9):837-47.
18. Ranasinghe P, Pigera S, Premakumara GS, Galappaththy P, Constantine GR, Katulanda PJBc, et al. Medicinal properties of ‘true’cinnamon (Cinnamomum zeylanicum): a systematic review. 2013;13(1):275.
19. Kurtzke JF. Rating neurologic impairment in multiple sclerosis an expanded disability status scale (EDSS). Neurology. 1983;33(11):1444-.
20. Pahan KJJoms. Prospects of cinnamon in multiple sclerosis. 2015;2(3):1000149.
21. Brahmachari S, Pahan KJTJoI. Sodium benzoate, a food additive and a metabolite of cinnamon, modifies T cells at multiple steps and inhibits adoptive transfer of experimental allergic encephalomyelitis. 2007;179(1):275-83.
22. Jana A, Modi KK, Roy A, Anderson JA, Van Breemen RB, Pahan KJJoNP. Up-regulation of neurotrophic factors by cinnamon and its metabolite sodium benzoate: therapeutic implications for neurodegenerative disorders. 2013;8(3):739-55.
23. Modi KK, Jana M, Mondal S, Pahan KJNr. Sodium benzoate, a metabolite of cinnamon and a food additive, upregulates ciliary neurotrophic factor in astrocytes and oligodendrocytes. 2015;40(11):2333-47.
24. Kundu M, Mondal S, Roy A, Martinson JL, Pahan KJTJoI. Sodium Benzoate, a Food Additive and a Metabolite of Cinnamon, Enriches Regulatory T Cells via STAT6-Mediated Upregulation of TGF-β. 2016:1501628.
25. Mondal S, Pahan KJPO. Cinnamon ameliorates experimental allergic encephalomyelitis in mice via regulatory T cells: implications for multiple sclerosis therapy. 2015;10(1):e0116566.
26. Kumar BA, Lakshman K, Nandeesh R, Saran GSJS, Technology, Journal AR. Evaluation of Antioxidant and Anti-amylase Activities of Sukhasarak Churna, an Ayurvedic Formulation. 2015;4(2):207-10.
27. Kokab S, Ahmad SJNRD, Pakistan Agriculture Research Council, Islamabad, Pakistan. Developing Herbal Pharmaceutics in Pakistan–II: Distinctiveness of Selected Medicinal Herbs and Uses. 2011;3:7-8.
28. Bajpai VK, Agrawal PJIJPE. Studies on phytochemicals, antioxidant, free radical scavenging and lipid peroxidation inhibitory effects of Trachyspermum ammi seeds. 2015;49:58-65.
29. Petramfar P, Moein M, Samani SM, Tabatabaei SH, Zarshenas MMJNS. Trachyspermum ammi 10% topical cream versus placebo on neuropathic pain, a randomized, double-blind, placebo-controlled trial. 2016;37(9):1449-55.
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Published
2019-04-26
How to Cite
Namjooyan, F., Ghanavati, R., Majdinasab, N., & Rezaei zadeh, H. (2019). The efficacy of traditional formulation on quality of life and fatigue in multiple sclerosis patients: a randomized double-blind placebo-control clinical trial. Journal of Contemporary Medical Sciences, 5(2), 96–100. https://doi.org/10.22317/jcms.v5i2.569
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