Therapeutic Effects of Hydralazine on Renal Ischemia-Reperfusion Injury in Rat.

Authors

  • Fatemeh Ahmadi Department of Physiology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.
  • Saeed Hajihashemi Department of Physiology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran. http://orcid.org/0000-0003-3854-3089
  • Ali Rahbari Department of Pathology, Arak University of Medical Sciences, Arak, Iran.
  • Fatemeh Ghanbari Department of Pharmacology, Islamic Azad University, Arak Branch, Arak, Iran.

DOI:

https://doi.org/10.22317/jcms.v5i6.622

Keywords:

Hydralazine, Renal Ischemia-Reperfusion Injury, Rat

Abstract

Objective: Renal ischemia-reperfusion (I-R) induces acute kidney injury (AKI). In this study, the effect of hydralazine was investigated on the renal injury induced by the I-R in rats.

Methods: AKI was induced with bilateral obstruction of the renal artery and vein for 20 minutes following with 24 hours of reperfusion. Hydralazine (5mg/kg) was injected intraperitoneally as post- treatment.

Results: Hydralazine significantly increased the levels of renal clearance of creatinine and renal blood flow, while was decreasing by I-R. Also, hydralazine significantly improved levels of serum electrolytes (sodium and potassium) that were impaired by I-R. The tissue MDA levels were significantly suppressed by hydralazine.

Conclusion: According to the results, the post treatment of hydralazine had a therapeutic effect on renal ischemia-reperfusion because improved ion reabsorption and excretion and increased renal blood flow and glomerular filtration rate and decreased lipid peroxidation.

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Published

2019-12-26

How to Cite

Ahmadi, F., Hajihashemi, S., Rahbari, A., & Ghanbari, F. (2019). Therapeutic Effects of Hydralazine on Renal Ischemia-Reperfusion Injury in Rat. Journal of Contemporary Medical Sciences, 5(6), 317–324. https://doi.org/10.22317/jcms.v5i6.622