Association between anti-Müllerian Hormone and other biomarkers with ovarian function in polycystic ovarian syndrome of Iraqi women

Abstract

Objectives: The current study aimed to investigate the role of of anti-Müllerian hormone and other hormonal biomarkers and insulin resistance in pathogenesis of polycystic ovarian syndrome of Iraqi women with various ages and BMI.

Method: The sublects include 50 cases of polycystic ovarian syndrome obtained from gynecological and obstetric teaching hospital, Kerbala health directorate / Kerbalaa, Iraq and another 50 apparently healthy women as a control group. with age ranged between (18-37) years during the period from Dec. 2019 to June, 2020 which was divided into two groups depending upon their age; first group with age (18-27) years and the second with age (28-37) years, also they divided into three subgroups depending upon the body mass index, normal weight (18.5-24.9 kg/m²), overweight (25-29.9 kg/m²), obesity (30-34.9 kg/m²) and  measurement of various hormonal levels were performed including LH, FSH, insulin, insulin resistance, total testosterone and anti-Müllerian hormone.

Results: A significant elevated levels of each of anti-Müllerian hormone (AMH), insulin, LH, total testosterone, prolactin, fasting blood glucose, FBG and insulin resistance while, a non-significant differences was found in FSH levels in women with PCOS as compared with control group.

Conclusion: A significant high levels of the all hormonal parameters including anti-Müllerian hormone, LH, prolactin and total testosterone  was found in women with PCOS as compared with the control, except the FSH values.