TY - JOUR AU - Shafeeq, Ahlam Adnan AU - Hamandi, Zaid Mohammed Ali AU - Mohammed, Mohammed Hassan AU - Al-Shamma, Ghassan PY - 2022/02/26 Y2 - 2024/03/29 TI - Synthesis, Characterization, and Antimicrobial Evaluation for New Azo-linked Derivative of Heterocyclic Compounds JF - Journal of Contemporary Medical Sciences JA - J. Contemp. Med. Sci. VL - 8 IS - 1 SE - Articles DO - 10.22317/jcms.v8i1.1153 UR - https://jocms.org/index.php/jcms/article/view/1153 SP - 51-58 AB - <p class="s6"><span class="s11">Objective</span><span class="s11">s:&nbsp;</span><span class="s13">Using different </span><span class="s13">activated </span><span class="s13">heterocyclic</span> <span class="s13">amines</span><span class="s13"> to prepare diazo</span><span class="s13">nium salt</span><span class="s13">s</span> <span class="s13">to be</span><span class="s13"> coupled with ornidazole</span><span class="s13"> (heterocyclic agent)</span><span class="s13"> to form the azo linkage</span> <span class="s13">compound</span><span class="s13">s</span><span class="s13"> (</span><span class="s13">A1</span><span class="s13">, A2</span><span class="s13">)</span> <span class="s13">as possible antimicrobial agent.</span></p><p class="s6"><span class="s11">M</span><span class="s11">ethod</span><span class="s11">s:</span> <span class="s13">T</span><span class="s13">he </span><span class="s13">synthetic process involves the preparation of diazonium salts by diazotization reaction of </span><span class="s13">s</span><span class="s13">ulfamethoxazole</span><span class="s13"> and 5</span><span class="s13">-ami</span><span class="s13">no-1,3,4-thiadiazole-2-thiol</span><span class="s13"> that contain primary amino group</span><span class="s13">s</span><span class="s13"> with (HNO2</span><span class="s13">) acid in the presence of HCl at about 0 </span><span class="s15">o</span><span class="s13">C</span><span class="s13">.</span> <span class="s13">T</span><span class="s13">hen</span><span class="s13">,</span> <span class="s13">azo compounds</span> <span class="s13">(</span><span class="s13">A1,</span> <span class="s13">A2</span><span class="s13">) were synthesized</span><span class="s13">, by the reaction of nitroimidazole derivative (ornidazole) with</span><span class="s13"> the pr</span><span class="s13">epared diazonium salts at 0-5 </span><span class="s15">o</span><span class="s13">C</span><span class="s13">,</span> <span class="s14">and</span> <span class="s13">the chemical structure of th</span><span class="s13">ese</span> <span class="s13">compound</span><span class="s13">s</span><span class="s13"> w</span><span class="s13">ere</span><span class="s13"> characterized and confirmed by measuring its</span> <span class="s13">Fourier Transform Infrared (FT-IR)</span> <span class="s13">spectrum </span><span class="s13">and Proton Nuclear Magnetic Resonance</span> <span class="s13">(H</span><span class="s15">1</span><span class="s13">-NMR) spectrum</span><span class="s13">. </span><span class="s13">&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; </span></p><p class="s6"><span class="s11">Results:&nbsp;</span><span class="s13">Thin layer chromatography and melti</span><span class="s13">ng point measurements were used </span><span class="s13">to establish the product’s purity. This compound was tested for anti</span><span class="s13">microbial</span><span class="s13"> activity using the broth microdilution spectrometric method on five different strains of bacteria and one strain of fungi, as well as the BACTEC MGIT 960 system for mycobacterium </span><span class="s13">tuberculosis</span> <span class="s13">bacilli.</span></p><p class="s6"><span class="s11">Conclusion:</span>&nbsp;<span class="s13">Using levofloxacin and nystatin as reference </span><span class="s13">drugs</span><span class="s13">, the </span><span class="s13">compoun</span><span class="s13">ds</span><span class="s13"> (</span><span class="s13">A1</span><span class="s13">, A2</span><span class="s13">) showed moderate to good action against tested gram</span><span class="s13">-</span><span class="s13">positive</span><span class="s13"> and</span> <span class="s13">gram-negative</span><span class="s13"> bacteria, and fungi, but no activity against </span><span class="s13">m</span><span class="s13">ycobacterium tuberculosis.</span>&nbsp;</p> ER -