TY - JOUR AU - Gholaminejhad, Morteza AU - Arabzadeh, Somayeh AU - Akbari, Mohammad AU - Mohamadi, Yousef AU - Hassanzadeh, Gholamreza PY - 2017/06/26 Y2 - 2024/03/29 TI - Anti-oxidative and neuroprotective effects of flaxseed on experimental unilateral spinal cord injury in rat JF - Journal of Contemporary Medical Sciences JA - J. Contemp. Med. Sci. VL - 3 IS - 10 SE - Articles DO - 10.22317/jcms.v3i10.168 UR - https://jocms.org/index.php/jcms/article/view/168 SP - 213-217 AB - <p><strong>Objectives</strong> Investigation of anti-oxidative and neuroprotective effects of flaxseed on rats with unilateral SCI.<br><strong>Methods</strong> 30 male Wistar rats were randomly assigned to five groups: control (Ctrl), laminectomy, flaxseed, spinal cord injured (SCI) and SCI + flaxseed (treatment) groups. SCI model was induced by placing a 50 g weight for 5 min on to a 2.2 mm × 2.5 mm platform applied to the dura at vertebral level T10. After 4 weeks, the blood of rats in different groups was collected and the influence of flaxseed on antioxidant enzymes and oxidative stress marker level, histologic alterations and locomotion score were assessed.<br><strong>Results</strong> Our results showed that in the SCI group, the mean level of Superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase<br>(CAT) were significantly decreased (P &lt; 0.01), whereas the mean malondialdehyde (MDA) content was significantly increased (P &lt; 0.001) in comparison to the laminectomy group. Furthermore, the mean levels of SOD, GPx and CAT in the treatment group was higher than the SCI group (P &lt; 0.001), while, the mean MDA content in the treatment group was significantly less than the SCI group (P &lt; 0.001). In addition, comparison between SCI and treatment groups determined a significant decrease in tissue degeneration and volume of cavities in the treatment group. However, Basso, Beattie and Bresnahan (BBB) scores were significantly increased in flaxseed-treated rats on days 14 (P &lt; 0.05), 21 and 28 (P &lt; 0.01) after surgery compared with the SCI group.<br><strong>Conclusions</strong> Our study for the first time showed the anti-oxidative and neuroprotective effects of flaxseed on experimental unilateral spinal cord injury in rat.<br><strong>Keywords</strong> spinal cord injury, flaxseed, oxidative stress, neuroprotective, anti-oxidative</p> ER -