TY - JOUR AU - Bahoush, Gholamreza AU - Pahlevani, Rozhin PY - 2020/12/26 Y2 - 2024/03/29 TI - Evaluation of the effectiveness and safety of N-Chromosome Royal Jelly on the number of peripheral white blood cells in patients with acute lymphoblastic leukemia JF - Journal of Contemporary Medical Sciences JA - J. Contemp. Med. Sci. VL - 6 IS - 6 SE - Articles DO - 10.22317/jcms.v6i6.887 UR - https://jocms.org/index.php/jcms/article/view/887 SP - 291-295 AB - <p><strong>Objectives: </strong>This study to investigate the immune response blood cells following N-Chromosome RJ administration in patients with childhood ALL.</p><p><strong>Methods: </strong>This single center before and after 12-weeks clinical trial was done in Ali-Asghar Children Hospital on twenty-six patients diagnosed with ALL during maintenance phase of chemotherapy. After collecting their demographics, patients received a starter dose of 2-gram processed new natural&nbsp;&nbsp; N-chromosome RJ before breakfast and were followed up each 2 weeks, counting their peripheral WBC, ANC and ALC by a blood cell count and differential analysis.</p><p><strong>Results: </strong>A total of Twenty-six patients were enrolled in this study (16 males and 10 females). Mean Peripheral WBC count of total patients were raised significantly after administering N-RJ Being 2510 ±1192 cells per cubic millimeter at the beginning and then raised to 4549±1500 cells per cubic millimeter at the end of trial. (P&lt;0.005) None of patients suffered from any adverse reaction during the trial.</p><p>There was a positive statistical relationship between total peripheral WBC, ANC and ALC count and N-Chromosome Royal jelly increased dosage, Being more prominent at the beginning of trial (p&lt;0.001) and the last two weeks of follow-ups. (p&lt;0.0005)</p><p><strong>Conclusion</strong>: This study has successfully demonstrated that N-chromosome RJ can be a promising immune- enhancing supplement in patients diagnosed with acute lymphoblastic leukemia in their complete remission and maintenance therapy time. In addition, it is a natural alternative for drugs like G-CSF, but without those long-term adverse effects, we can see in G-CSF drugs.</p> ER -