The Relationship between Vitamin D, Body Mass Index and some Dietary Products with Acne Vulgaris; A Case-Control study in Baghdad/Iraq

Authors

  • Sarah Haider Zalzala Family Medicine Specialist, Baghdad, Iraq
  • Besmah Mohammad Ali Iraqi Ministry of Health, Ghazi Al-Hariri Hospital for Surgical Specialities, Medical City directorate, Baghdad, Iraq
  • Zahraa Saeed Fahad Dermatology department, Al-Yarmouk Teaching Hospital, Baghdad, Iraq

DOI:

https://doi.org/10.22317/jcms.v10i1.1459

Keywords:

Acne Vulgaris, dairy products, chocolate, BMI

Abstract

Objective: To investigate the association of vitamin D level and moderate to severe acne as a primary outcome, and its association with BMI, dairy products, and chocolate consumption.

Subjects and Methods: A case-control study was conducted in a dermatology outpatient clinic. Patients, diagnosed with moderate to severe acne vulgaris that warrant treatment with oral antibiotics, and had global acne grading system (GAGS) score of >=19 were eligible to be selected as cases. Aged matched, with no or mild cases of acne were eligible to be selected as controls. The participant height, weight, BMI, and serum circulating 25-hydroxyvitamin D level were measured. A modified food frequency questionnaire was used for dietary history.

Results: Comparing Cases (N = 101) and Control (N = 134), the mean of vitamin D level in cases were lower than that in the controls, however no statistically significant difference is observed. There were statistically insignificant differences between the studied groups regarding milk (whole, low fat, skimmed and any type of milk), cheese, yogurt, other dairy products, and chocolate consumption. However, a statistically significant disparity in weight is noted, but not in BMI.

Conclusion: The results did not reveal any statistically significant associations between vitamin D level, BMI, dairy and chocolate consumption, and moderate to severe acne. However, it is important to note that this does not definitively rule out the possibility of any potential relationships or effects.

References

Layton AM, Thiboutot D, Tan J. Reviewing the global burden of acne: how could we improve care to reduce the burden? British Journal of Dermatology [Internet]. 2021 Feb 1 [cited 2023 Dec 4];184(2):219–25. Available from: https://dx.doi.org/10.1111/bjd.19477

Tan J, Beissert S, Cook-Bolden F, Chavda R, Harper J, Hebert A, et al. Impact of facial and truncal acne on quality of life: A multi-country population-based survey. JAAD Int. 2021 Jun 1;3:102–10.

Sachdeva M, Tan J, Lim J, Kim M, Nadeem I, Bismil R. The prevalence, risk factors, and psychosocial impacts of acne vulgaris in medical students: a literature review. Int J Dermatol [Internet]. 2021 Jul 1 [cited 2023 Dec 4];60(7):792–8. Available from: https://pubmed.ncbi.nlm.nih.gov/33128470/

Yang J, Yang H, Xu A, He L. A Review of Advancement on Influencing Factors of Acne: An Emphasis on Environment Characteristics. Front Public Health. 2020 Sep 17;8:551037.

O’Neill AM, Gallo RL. Host-microbiome interactions and recent progress into understanding the biology of acne vulgaris. Microbiome 2018 6:1 [Internet]. 2018 Oct 2 [cited 2023 Sep 2];6(1):1–16. Available from: https://link.springer.com/articles/10.1186/s40168-018-0558-5

Hazarika N. Acne vulgaris: new evidence in pathogenesis and future modalities of treatment. https://doi.org/101080/0954663420191654075 [Internet]. 2019 [cited 2023 Sep 2];32(3):277–85. Available from: https://www.tandfonline.com/doi/abs/10.1080/09546634.2019.1654075

Kraaijvanger R, Veltkamp M. The Role of Cutibacterium acnes in Sarcoidosis: From Antigen to Treatable Trait? Microorganisms 2022, Vol 10, Page 1649 [Internet]. 2022 Aug 15 [cited 2023 Sep 3];10(8):1649. Available from: https://www.mdpi.com/2076-2607/10/8/1649/htm

Roger Bouillon. Vitamin D and extraskeletal health [Internet]. [cited 2023 Sep 2]. Available from: https://medilib.ir/uptodate/show/13915

Agak GW, Qin M, Nobe J, Kim MH, Krutzik SR, Tristan GR, et al. Propionibacterium acnes Induces an IL-17 Response in Acne Vulgaris that Is Regulated by Vitamin A and Vitamin D. Journal of Investigative Dermatology. 2014 Feb 1;134(2):366–73.

Holick M.F. Vitamin D: extraskeletal health. Rheumatic Disease Clinics. 2012;38(1):141–160.

Diane Thiboutot, Andrea L Zaenglein. Pathogenesis, clinical manifestations, and diagnosis of acne vulgaris - UpToDate [Internet]. [cited 2023 Sep 3]. Available from: https://www.uptodate.com/contents/pathogenesis-clinicalmanifestations-and-diagnosis-of-acne-vulgaris?search=pathogenesisi%20acne&source=search_result&selectedTitle=1~150&usage_type=default&display_rank=1

Bungau SG, Tit DM, Vesa CM, Abid A, Szilagyi DV, Radu AF, et al. Non-conventional therapeutical approaches to acne vulgaris related to its association with metabolic disorders. Eur J Pharmacol. 2022 May 15;923:174936.

Thappa DM, Adityan B, Kumari R. Scoring systems in acne vulgaris. Indian J Dermatol Venereol Leprol [Internet]. 2009 May 1 [cited 2023 Sep 9];75(3):323. Available from: https://ijdvl.com/scoring-systems-in-acne-vulgaris/

Doshi A, Zaheer A, Stiller MJ. A comparison of current acne grading systems and proposal of a novel system. Int J Dermatol [Internet]. 1997 Jun 1 [cited 2023 Sep 9];36(6):416–8. Available from: https://onlinelibrary.wiley.com/doi/full/10.1046/j.1365-4362.1997.00099.x

Liu CW, Tan J. Acne Severity Grading: Determining Essential Clinical Component and Features. Cutaneous Biometrics [Internet]. 2019 [cited 2023 Sep 9];1–8. Available from: https://link.springer.com/referenceworkentry/10.1007/978-3-319-56591-0_22-1

Calculator: Body mass index (BMI; Quetelet’s index) in adults - UpToDate [Internet]. [cited 2023 Sep 13]. Available from: https://www.uptodate.com/contents/calculator-body-mass-index-bmi-quetelets-index-in-adults

Dietary Guidelines for Americans, 2020-2025 | Enhanced Reader.

Zhao B, Gan L, Yu K, Männistö S, Huang J, Albanes D. Relationship between chocolate consumption and overall and cause-specific mortality, systematic review and updated meta-analysis. Eur J Epidemiol [Internet]. 2022 Apr 1 [cited 2023 Sep 13];37(4):321–33. Available from: https://link.springer.com/article/10.1007/s10654-022-00858-5

Bess Dawson-Hughes. Vitamin D deficiency in adults: Definition, clinical manifestations, and treatment - UpToDate [Internet]. [cited

Sep 3]. Available from: https://www.uptodate.com/contents/vitamin-d-deficiency-in-adults-definition-clinical-manifestationsand-

treatment?search=vitamin%20d%20deficiency&source=search_result&selectedTitle=1~150&usage_type=default&display_rank=1#H2

Ameen SO, Rasool BQ, Mohammad AN, Tahr SM, Abdulla GN, Omar DA, et al. Prevalence and determinants of vitamin D deficiency amongst patients in Erbil, Kurdistan region of Iraq. Journal of Clinical Medicine of Kazakhstan. 2023 Jun 28;20(3):19–25.

van Schoor N, de Jongh R, Lips P. Worldwide vitamin D status. Feldman and Pike’s Vitamin D. 2024 Jan 1;47–75.

Hasamoh Y, Thadanipon K, Juntongjin P. Association between Vitamin D Level and Acne, and Correlation with Disease Severity: A Meta-Analysis. Dermatology [Internet]. 2022 May 2 [cited 2023 Dec 2];238(3):404–11. Available from: https://dx.doi.org/10.1159/000517514

Rasti S, Dewinta N, Kamal R, Adissadah A, Madanny A, Dewanti L. Correlation between Serum 25-Hydroxy Vitamin D Levels and the Severity of Acne Vulgaris: A Systematic Review. Indian J Dermatol [Internet]. 2022 Jan 1 [cited 2023 Dec 2];67(1):31. Available from: /pmc/articles/PMC9154172/

Asmaa Awni Haydar. Estimation of serum 25-hydroxy vitamin D and zinc levels in patients with acne vulgaris and their association with disease severity | Request PDF [Internet]. [cited 2023 Dec 3]. Available from: https://www.researchgate.net/publication/344273556_Estimation_of_serum_25-hydroxy_vitamin_D_and_zinc_levels_in_patients_with_acne_vulgaris_and_their_association_with_disease_severity

Meixiong J, Ricco C, Vasavda C, Ho BK. Diet and acne: A systematic review. JAAD Int [Internet]. 2022 Jun 1 [cited 2023 Dec 2];7:95–112. Available from: https://pubmed.ncbi.nlm.nih.gov/35373155/

Rasool ZS, AKBAY C. Fast Food Consumption Behavior of Consumers in the Northern Region of Iraq. EURASIAN JOURNAL OF AGRICULTURAL ECONOMICS (EJAE) [Internet]. 2021 Apr 2 [cited 2023 Dec 3];1(1):1–13. Available from: http://jeae.org/index.php/JEAE/article/view/11

Ulvestad M, Bjertness E, Dalgard F, Halvorsen JA. Acne and dairy products in adolescence: results from a Norwegian longitudinal study. J Eur Acad Dermatol Venereol [Internet]. 2017 Mar 1 [cited 2023 Dec 2];31(3):530–5. Available from: https://pubmed.ncbi.nlm.nih.gov/27422392/

Aalemi AK, Anwar I, Chen H. Dairy consumption and acne: A case control study in kabul, afghanistan. Clin Cosmet Investig Dermatol [Internet]. 2019 [cited 2023 Dec 3];12:481–7. Available from: http://doi.org/10.2147/CCID.S195191

Aghasi M, Golzarand M, Shab-Bidar S, Aminianfar A, Omidian M, Taheri F. Dairy intake and acne development: A meta-analysis of observational studies. Clinical Nutrition. 2019 Jun 1;38(3):1067–75.

Ismail NH, Manaf ZA, Azizan NZ. High glycemic load diet, milk and ice cream consumption are related to acne vulgaris in Malaysian young adults: a case control study. BMC Dermatol [Internet]. 2012 Aug 16 [cited 2023 Dec 3];12(1):1–8. Available from: https://link.springer.com/articles/10.1186/1471-5945-12-13

Juhl CR, Bergholdt HKM, Miller IM, Jemec GBE, Kanters JK, Ellervik C. Dairy Intake and Acne Vulgaris: A Systematic Review and Meta-Analysis of 78,529 Children, Adolescents, and Young Adults. Nutrients [Internet]. 2018 Aug 9 [cited 2023 Dec 2];10(8). Available from: /pmc/articles/PMC6115795/

Bajelan A, Ghaebi M, Javadi M, Barikani A, Beheshti A, Bargahi M, et al. The Association Between the Incidence of Acne Vulgaris and Lifestyle Factors Including Dietary Habits, Physical Activity, and Bathing Frequency. Journal of Skin and Stem Cell 2020 7:3 [Internet]. 2020 Apr 6 [cited 2023 Dec 3];7(3):114161. Available from: https://brieflands.com/articles/jssc-114161.html

Daszkiewicz M. Associations between diet and acne lesions. Rocz Panstw Zakl Hig [Internet]. 2021 [cited 2023 Dec 3];72(2):137–43. Available from: http://wydawnictwa.pzh.gov.pl/roczniki_pzh/

Conforti C, Agozzino M, Emendato G, Fai A, Fichera F, Marangi GF, et al. Acne and diet: a review. Int J Dermatol [Internet]. 2022 Aug 1 [cited 2023 Dec 3];61(8):930–4. Available from: https://pubmed.ncbi.nlm.nih.gov/34423427/

Łożyńska K, Głabska D. Association between Nutritional Behaviours and Acne-Related Quality of Life in a Population of Polish Male Adolescents. Nutrients 2022, Vol 14, Page 2677 [Internet]. 2022 Jun 28 [cited 2023 Dec 2];14(13):2677. Available from: https://www.mdpi.com/2072-6643/14/13/2677/htm

Goodarzi A, Roohaninasab M, Behrangi E, Ghassemi M, Ghahremani AP, Teymoori N. Serum parameters, diet and body mass index in acne vulgaris: a mini review. Iranian Journal of Dermatology [Internet]. 2020 Apr 1 [cited 2023 Dec 3];23(1):32–4. Available from: https://www.iranjd.ir/article_108067.html

High Body Mass Index is a Risk Factor for Acne Severity in Adolescents: A Preliminary Report - PubMed [Internet]. [cited 2023 Dec 3]. Available from: https://pubmed.ncbi.nlm.nih.gov/31351501/

Overview | Acne vulgaris: management | Guidance | NICE.

Downloads

Published

2024-02-26

How to Cite

Zalzala, S. H., Ali, B. M., & Fahad, Z. S. (2024). The Relationship between Vitamin D, Body Mass Index and some Dietary Products with Acne Vulgaris; A Case-Control study in Baghdad/Iraq. Journal of Contemporary Medical Sciences, 10(1). https://doi.org/10.22317/jcms.v10i1.1459