Relationship between serine/threonine kinase 39 gene polymorphisms with some cardiac biomarkers in hypertensive patients

Abstract

Aim This study aimed to evaluate the association between STK39 SNP rs35929607 and some cardiovascular risk factors in hypertension
patients in holy Kerbala city, Iraq.
Materials and Methods We included 74 hypertensive patients with no signs and symptoms of renal impairment and another 30 control subjects.
The links between genotype and hypertension were examined. Then, the SNP related variances in the blood pressure and remaining
cardiovascular risk factors were studied.
Results There is no significant association between STK39 rs35929607 and hypertension in current study. However Allele A showed a
significant association in hypertensive patient compared with control group particularly in female gender. The hypertensive patients
showed a significant higher result in age, BMI, FBS, total cholesterol, and STG, LDL-C and lower level in HDL-C.
Conclusion The association between the SNP rs35929607ofSTK3 and hypertension was not significant in current study in Kerbala population
of Iraq. Furthermore, only Allele A showed a significant association with hypertension in females group. Further studies needed to clarify
the effect of other STK39 variants on these cardiovascular risk factors.