Triiodothyronine Improves Morphology and Up-regulates seladin-1 of neurospheres extracted from Subventricular Zone in Streptozotocin-induced rat model of Alzheimer's disease
DOI:
https://doi.org/10.22317/jcms.v6i1.735Abstract
Objectives: In this study, the effects of triiodothyronine (T3) on neurospheres isolated from SVZ of AD induced rats were examined.
Methods: Eighteen male Wistar rats were classified into two groups: Sham (Sh) and STZ (Streptozotocin injected, 1.5 mg/kg in each lateral ventricle on days 1 and 3 after recovery). On day 21, the SVZ was extracted and neurospheres were cultured. T3 (50 nM) was added to the culture medium (STZ+T3 group) and then, the morphology and seladin-1 gene expression of neurospheres were evaluated.
Results: The diameter and the number of neurospheres along with the gene expression of seladin-1 were significantly decreased in the STZ group compared to Sh group (PË‚0.05) while the administration of T3 significantly (PË‚0.05) increased all these parameters in the STZ group.
Conclusion: STZ decreases the proliferation of stem cells extracted from SVZ and administration of T3 to the culture media improves the morphology and up-regulates the gene expression of seladin-1 of neurospheres.
References
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19. Genovese T, Impellizzeri D, Ahmad A, Cornelius C, Campolo M, Cuzzocrea S, et al. Post-ischaemic thyroid hormone treatment in a rat model of acute stroke. Brain research. 2013;1513:92-102.
20. Mahakizadeh S, Akbari M, Sharifzadeh M, Rastegar T, Abolhassani F, Hassanzadeh G. Wharton’jelly mesenchymal stem cells and insulin effect on BDNF expression in CA1 and CA3 regions of rats’ hippocampus after chronic hypoxia. Journal of Contemporary Medical Sciences. 2018;4(2):63-9.
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22. Sutherland GT, Chami B, Youssef P, Witting PK. Oxidative stress in Alzheimer's disease: Primary villain or physiological by-product? Redox Report. 2013;18(4):134-41.
23. Schrag M, Mueller C, Zabel M, Crofton A, Kirsch W, Ghribi O, et al. Oxidative stress in blood in Alzheimer's disease and mild cognitive impairment: a meta-analysis. Neurobiology of disease. 2013;59:100-10.
24. Butterfield DA, Reed T, Newman SF, Sultana R. Roles of amyloid β-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment. Free Radical Biology and Medicine. 2007;43(5):658-77.
25. Beal MF. Mitochondrial dysfunction and oxidative damage in Alzheimer's and Parkinson's diseases and coenzyme Q 10 as a potential treatment. Journal of bioenergetics and biomembranes. 2004;36(4):381-6.
26. Sultana R, Butterfield DA. Role of oxidative stress in the progression of Alzheimer's disease. Journal of Alzheimer's Disease. 2010;19(1):341-53.
27. Grieb P. Intracerebroventricular streptozotocin injections as a model of Alzheimer’s disease: in search of a relevant mechanism. Molecular neurobiology. 2016;53(3):1741-52.
28. Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiological reviews. 2001;81(2):741-66.
29. Thompson PM, Hayashi KM, Dutton RA, CHIANG MC, Leow AD, Sowell ER, et al. Tracking Alzheimer's disease. Annals of the New York Academy of Sciences. 2007;1097(1):183-214.
30. Thompson PM, Hayashi KM, De Zubicaray G, Janke AL, Rose SE, Semple J, et al. Dynamics of gray matter loss in Alzheimer's disease. Journal of neuroscience. 2003;23(3):994-1005.
31. Al-Mahmood S, Colin S, Schneider C. Composition comprising an antisense sequence implicated in the regulation of angiogenesis. Google Patents; 2012.
32. Taupin P, Gage FH. Adult neurogenesis and neural stem cells of the central nervous system in mammals. Journal of neuroscience research. 2002;69(6):745-9.
33. Seaberg RM, Van Der Kooy D. Adult rodent neurogenic regions: the ventricular subependyma contains neural stem cells, but the dentate gyrus contains restricted progenitors. Journal of Neuroscience. 2002;22(5):1784-93.
34. Abrous DN, Koehl M, Le Moal M. Adult neurogenesis: from precursors to network and physiology. Physiological reviews. 2005;85(2):523-69.
35. Feng R, Rampon C, Tang Y-P, Shrom D, Jin J, Kyin M, et al. Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces. Neuron. 2001;32(5):911-26.
36. Haughey NJ, Nath A, Chan SL, Borchard A, Rao MS, Mattson MP. Disruption of neurogenesis by amyloid βâ€peptide, and perturbed neural progenitor cell homeostasis, in models of Alzheimer's disease. Journal of neurochemistry. 2002;83(6):1509-24.
37. Wang R, Dineley K, Sweatt J, Zheng H. Presenilin 1 familial Alzheimer's disease mutation leads to defective associative learning and impaired adult neurogenesis. Neuroscience. 2004;126(2):305-12.
38. Zhang C, McNeil E, Dressler L, Siman R. Long-lasting impairment in hippocampal neurogenesis associated with amyloid deposition in a knock-in mouse model of familial Alzheimer's disease. Experimental neurology. 2007;204(1):77-87.
39. Ceresini G, Lauretani F, Maggio M, Ceda GP, Morganti S, Usberti E, et al. Thyroid function abnormalities and cognitive impairment in elderly people: results of the Invecchiare in Chianti study. Journal of the American Geriatrics Society. 2009;57(1):89-93.
40. Kalmijn S, Mehta KM, Pols HA, Hofman A, Drexhage HA, Breteler MM. Subclinical hyperthyroidism and the risk of dementia. The Rotterdam study. Clinical endocrinology. 2000;53(6):733-7.
41. Lopez OL, Rabin BS, Huff FJ, Rezek D, Reinmuth OM. Serum autoantibodies in patients with Alzheimer's disease and vascular dementia and in nondemented control subjects. Stroke. 1992;23(8):1078-83.
42. Ewins DL, Rossor MN, Butler J, Rogues PK, Mullen MJ, McGregor AM. Association between autoimmune thyroid disease and Familial Alzheimers disease. Clinical endocrinology. 1991;35(1):93-6.
43. Ganguli M, Burmeister LA, Seaberg EC, Belle S, DeKosky ST. Association between dementia and elevated TSH: a community-based study. Biological psychiatry. 1996;40(8):714-25.
44. Ishida E, Hashimoto K, Okada S, Satoh T, Yamada M, Mori M. Crosstalk between thyroid hormone receptor and liver X receptor in the regulation of selective Alzheimer’s disease indicator-1 gene expression. PloS one. 2013;8(1):e54901.
45. Waterham HR, Koster J, Romeijn GJ, Hennekam RC, Vreken P, Andersson HC, et al. Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis. American journal of human genetics. 2001;69(4):685-94.
46. Greeve I, Hermans-Borgmeyer I, Brellinger C, Kasper D, Gomez-Isla T, Behl C, et al. The human DIMINUTO/DWARF1 homolog seladin-1 confers resistance to Alzheimer's disease-associated neurodegeneration and oxidative stress. Journal of Neuroscience. 2000;20(19):7345-52.
47. Martin M, Dotti CG, Ledesma MD. Brain cholesterol in normal and pathological aging. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids. 2010;1801(8):934-44.
48. Benvenuti S, Luciani P, Cellai I, Deledda C, Baglioni S, Saccardi R, et al. Thyroid hormones promote cell differentiation and up-regulate the expression of the seladin-1 gene in in vitro models of human neuronal precursors. Journal of Endocrinology. 2008;197(2):437-46.
49. Mokhtari T, Akbari M, Malek F, Kashani IR, Rastegar T, Noorbakhsh F, et al. Improvement of memory and learning by intracerebroventricular microinjection of T3 in rat model of ischemic brain stroke mediated by upregulation of BDNF and GDNF in CA1 hippocampal region. DARU Journal of Pharmaceutical Sciences. 2017;25(1):4.
2. Hassanzadeh G, Hosseini A, Pasbakhsh P, Akbari M, Ghaffarpour M, Takzare N, et al. Trimetazidine prevents oxidative changes induced in a rat model of sporadic type of Alzheimer's disease. Acta Medica Iranica. 2015;53(1):17-24.
3. Kumar A, Singh A. A review on Alzheimer's disease pathophysiology and its management: an update. Pharmacological Reports. 2015;67(2):195-203.
4. Hassanzadeh G, Fallahi Z, Khanmohammadi M, Elmizadeh H, Sharifzadeh M, Nouri K, et al. Effect of Magnetic Tacrine-Loaded Chitosan Nanoparticles on Spatial Learning, Memory, Amyloid Precursor Protein and Seladin-1 Expression in the Hippocampus of Streptozotocin-Exposed Rats. International Clinical Neuroscience Journal. 2016;3(1):25-31.
5. Peri A, Serio M. Neuroprotective effects of the Alzheimer's disease-related gene seladin-1. Journal of Molecular Endocrinology. 2008;41(5):251-61.
6. Condello C, Lemmin T, Stöhr J, Nick M, Wu Y, Maxwell AM, et al. Structural heterogeneity and intersubject variability of Aβ in familial and sporadic Alzheimer’s disease. Proceedings of the National Academy of Sciences. 2018:201714966.
7. Biasibetti R, dos Santos JPA, Rodrigues L, Wartchow KM, Suardi LZ, Nardin P, et al. Hippocampal changes in STZ-model of Alzheimer’s disease are dependent on sex. Behavioural brain research. 2017;316:205-14.
8. Guigon CJ, Zhao L, Lu C, Willingham MC, Cheng S-y. Regulation of β-catenin by a novel nongenomic action of thyroid hormone β receptor. Molecular and cellular biology. 2008;28(14):4598-608.
9. Mozhdeh HP, Zeynali B, Aligholi H, Radgerdi IK, Negah SS, Hassanzadeh G. The effect of intracerebroventricular administration of streptozocin on cell proliferation in subventricular zone stem cells in a rat model of alzheimer’s disease. Neurosci J Shefaye Khatam. 2015;3:80-6.
10. Andreotti JP, Lousado L, Magno LAV, Birbrair A. Hypothalamic neurons take center stage in the neural stem cell niche. Cell Stem Cell. 2017;21(3):293-4.
11. Shan X, Tomlinson L, Yang Q, Colognato H. Distinct Requirements for Extracellular and Intracellular MMP12 in the Development of the Adult V-SVZ Neural Stem Cell Niche. Stem cell reports. 2018;10(3):984-99.
12. Corsini NS, Knoblich JA. Tracing Stem Cell Division in Adult Neurogenesis. Cell stem cell. 2018;22(2):143-5.
13. Aligholi H, Hassanzadeh G, Azari H, Rezayat SM, Mehr SE, Akbari M, et al. A new and safe method for stereotactically harvesting neural stem/progenitor cells from the adult rat subventricular zone. Journal of neuroscience methods. 2014;225:81-9.
14. Doetsch F, Caille I, Lim DA, GarcÃa-Verdugo JM, Alvarez-Buylla A. Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell. 1999;97(6):703-16.
15. Fuentealba LC, Obernier K, Alvarez-Buylla A. Adult neural stem cells bridge their niche. Cell stem cell. 2012;10(6):698-708.
16. Xiong L-L, Chen Z-W, Wang T-H. Nerve growth factor promotes in vitro proliferation of neural stem cells from tree shrews. Neural regeneration research. 2016;11(4):591-6.
17. De Escobar GM, Obregón MJ, Del Rey FE. Role of thyroid hormone during early brain development. European Journal of Endocrinology. 2004;151(Suppl 3):U25-U37.
18. Yen PM. Physiological and molecular basis of thyroid hormone action. Physiological reviews. 2001;81(3):1097-142.
19. Genovese T, Impellizzeri D, Ahmad A, Cornelius C, Campolo M, Cuzzocrea S, et al. Post-ischaemic thyroid hormone treatment in a rat model of acute stroke. Brain research. 2013;1513:92-102.
20. Mahakizadeh S, Akbari M, Sharifzadeh M, Rastegar T, Abolhassani F, Hassanzadeh G. Wharton’jelly mesenchymal stem cells and insulin effect on BDNF expression in CA1 and CA3 regions of rats’ hippocampus after chronic hypoxia. Journal of Contemporary Medical Sciences. 2018;4(2):63-9.
21. Sabbaghziarani F, Mortezaee K, Akbari M, Soleimani M, Moini A, Ataeinejad N, et al. Retinoic acid-pretreated Wharton’s jelly mesenchymal stem cells in combination with triiodothyronine improve expression of neurotrophic factors in the subventricular zone of the rat ischemic brain injury. Metabolic Brain Disease. 2017;32(1):185-93.
22. Sutherland GT, Chami B, Youssef P, Witting PK. Oxidative stress in Alzheimer's disease: Primary villain or physiological by-product? Redox Report. 2013;18(4):134-41.
23. Schrag M, Mueller C, Zabel M, Crofton A, Kirsch W, Ghribi O, et al. Oxidative stress in blood in Alzheimer's disease and mild cognitive impairment: a meta-analysis. Neurobiology of disease. 2013;59:100-10.
24. Butterfield DA, Reed T, Newman SF, Sultana R. Roles of amyloid β-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment. Free Radical Biology and Medicine. 2007;43(5):658-77.
25. Beal MF. Mitochondrial dysfunction and oxidative damage in Alzheimer's and Parkinson's diseases and coenzyme Q 10 as a potential treatment. Journal of bioenergetics and biomembranes. 2004;36(4):381-6.
26. Sultana R, Butterfield DA. Role of oxidative stress in the progression of Alzheimer's disease. Journal of Alzheimer's Disease. 2010;19(1):341-53.
27. Grieb P. Intracerebroventricular streptozotocin injections as a model of Alzheimer’s disease: in search of a relevant mechanism. Molecular neurobiology. 2016;53(3):1741-52.
28. Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiological reviews. 2001;81(2):741-66.
29. Thompson PM, Hayashi KM, Dutton RA, CHIANG MC, Leow AD, Sowell ER, et al. Tracking Alzheimer's disease. Annals of the New York Academy of Sciences. 2007;1097(1):183-214.
30. Thompson PM, Hayashi KM, De Zubicaray G, Janke AL, Rose SE, Semple J, et al. Dynamics of gray matter loss in Alzheimer's disease. Journal of neuroscience. 2003;23(3):994-1005.
31. Al-Mahmood S, Colin S, Schneider C. Composition comprising an antisense sequence implicated in the regulation of angiogenesis. Google Patents; 2012.
32. Taupin P, Gage FH. Adult neurogenesis and neural stem cells of the central nervous system in mammals. Journal of neuroscience research. 2002;69(6):745-9.
33. Seaberg RM, Van Der Kooy D. Adult rodent neurogenic regions: the ventricular subependyma contains neural stem cells, but the dentate gyrus contains restricted progenitors. Journal of Neuroscience. 2002;22(5):1784-93.
34. Abrous DN, Koehl M, Le Moal M. Adult neurogenesis: from precursors to network and physiology. Physiological reviews. 2005;85(2):523-69.
35. Feng R, Rampon C, Tang Y-P, Shrom D, Jin J, Kyin M, et al. Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces. Neuron. 2001;32(5):911-26.
36. Haughey NJ, Nath A, Chan SL, Borchard A, Rao MS, Mattson MP. Disruption of neurogenesis by amyloid βâ€peptide, and perturbed neural progenitor cell homeostasis, in models of Alzheimer's disease. Journal of neurochemistry. 2002;83(6):1509-24.
37. Wang R, Dineley K, Sweatt J, Zheng H. Presenilin 1 familial Alzheimer's disease mutation leads to defective associative learning and impaired adult neurogenesis. Neuroscience. 2004;126(2):305-12.
38. Zhang C, McNeil E, Dressler L, Siman R. Long-lasting impairment in hippocampal neurogenesis associated with amyloid deposition in a knock-in mouse model of familial Alzheimer's disease. Experimental neurology. 2007;204(1):77-87.
39. Ceresini G, Lauretani F, Maggio M, Ceda GP, Morganti S, Usberti E, et al. Thyroid function abnormalities and cognitive impairment in elderly people: results of the Invecchiare in Chianti study. Journal of the American Geriatrics Society. 2009;57(1):89-93.
40. Kalmijn S, Mehta KM, Pols HA, Hofman A, Drexhage HA, Breteler MM. Subclinical hyperthyroidism and the risk of dementia. The Rotterdam study. Clinical endocrinology. 2000;53(6):733-7.
41. Lopez OL, Rabin BS, Huff FJ, Rezek D, Reinmuth OM. Serum autoantibodies in patients with Alzheimer's disease and vascular dementia and in nondemented control subjects. Stroke. 1992;23(8):1078-83.
42. Ewins DL, Rossor MN, Butler J, Rogues PK, Mullen MJ, McGregor AM. Association between autoimmune thyroid disease and Familial Alzheimers disease. Clinical endocrinology. 1991;35(1):93-6.
43. Ganguli M, Burmeister LA, Seaberg EC, Belle S, DeKosky ST. Association between dementia and elevated TSH: a community-based study. Biological psychiatry. 1996;40(8):714-25.
44. Ishida E, Hashimoto K, Okada S, Satoh T, Yamada M, Mori M. Crosstalk between thyroid hormone receptor and liver X receptor in the regulation of selective Alzheimer’s disease indicator-1 gene expression. PloS one. 2013;8(1):e54901.
45. Waterham HR, Koster J, Romeijn GJ, Hennekam RC, Vreken P, Andersson HC, et al. Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis. American journal of human genetics. 2001;69(4):685-94.
46. Greeve I, Hermans-Borgmeyer I, Brellinger C, Kasper D, Gomez-Isla T, Behl C, et al. The human DIMINUTO/DWARF1 homolog seladin-1 confers resistance to Alzheimer's disease-associated neurodegeneration and oxidative stress. Journal of Neuroscience. 2000;20(19):7345-52.
47. Martin M, Dotti CG, Ledesma MD. Brain cholesterol in normal and pathological aging. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids. 2010;1801(8):934-44.
48. Benvenuti S, Luciani P, Cellai I, Deledda C, Baglioni S, Saccardi R, et al. Thyroid hormones promote cell differentiation and up-regulate the expression of the seladin-1 gene in in vitro models of human neuronal precursors. Journal of Endocrinology. 2008;197(2):437-46.
49. Mokhtari T, Akbari M, Malek F, Kashani IR, Rastegar T, Noorbakhsh F, et al. Improvement of memory and learning by intracerebroventricular microinjection of T3 in rat model of ischemic brain stroke mediated by upregulation of BDNF and GDNF in CA1 hippocampal region. DARU Journal of Pharmaceutical Sciences. 2017;25(1):4.
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Published
2020-02-26
How to Cite
Mokhtari, T., Mahahakizadeh, S., Aligholi, H., Ijaz, S., Noori, L., & Hassanzadeh, G. (2020). Triiodothyronine Improves Morphology and Up-regulates seladin-1 of neurospheres extracted from Subventricular Zone in Streptozotocin-induced rat model of Alzheimer’s disease. Journal of Contemporary Medical Sciences, 6(1), 32–38. https://doi.org/10.22317/jcms.v6i1.735
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